DNA damage in Wistar Kyoto rats exercised during pregnancy

Detalhes bibliográficos
Autor(a) principal: Corrêa,Mikaela da Silva
Data de Publicação: 2017
Outros Autores: Gelaleti,Rafael Bottaro, Bento,Giovana Fernanda, Damasceno,Débora Cristina, Peraçoli,José Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000500388
Resumo: Abstract Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage. Results: Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05). Conclusion: The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.
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spelling DNA damage in Wistar Kyoto rats exercised during pregnancyPregnancyExerciseDNA DamageRatsAbstract Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage. Results: Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05). Conclusion: The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000500388Acta Cirúrgica Brasileira v.32 n.5 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170050000008info:eu-repo/semantics/openAccessCorrêa,Mikaela da SilvaGelaleti,Rafael BottaroBento,Giovana FernandaDamasceno,Débora CristinaPeraçoli,José Carloseng2017-06-02T00:00:00Zoai:scielo:S0102-86502017000500388Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-06-02T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv DNA damage in Wistar Kyoto rats exercised during pregnancy
title DNA damage in Wistar Kyoto rats exercised during pregnancy
spellingShingle DNA damage in Wistar Kyoto rats exercised during pregnancy
Corrêa,Mikaela da Silva
Pregnancy
Exercise
DNA Damage
Rats
title_short DNA damage in Wistar Kyoto rats exercised during pregnancy
title_full DNA damage in Wistar Kyoto rats exercised during pregnancy
title_fullStr DNA damage in Wistar Kyoto rats exercised during pregnancy
title_full_unstemmed DNA damage in Wistar Kyoto rats exercised during pregnancy
title_sort DNA damage in Wistar Kyoto rats exercised during pregnancy
author Corrêa,Mikaela da Silva
author_facet Corrêa,Mikaela da Silva
Gelaleti,Rafael Bottaro
Bento,Giovana Fernanda
Damasceno,Débora Cristina
Peraçoli,José Carlos
author_role author
author2 Gelaleti,Rafael Bottaro
Bento,Giovana Fernanda
Damasceno,Débora Cristina
Peraçoli,José Carlos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Corrêa,Mikaela da Silva
Gelaleti,Rafael Bottaro
Bento,Giovana Fernanda
Damasceno,Débora Cristina
Peraçoli,José Carlos
dc.subject.por.fl_str_mv Pregnancy
Exercise
DNA Damage
Rats
topic Pregnancy
Exercise
DNA Damage
Rats
description Abstract Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage. Results: Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05). Conclusion: The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.
publishDate 2017
dc.date.none.fl_str_mv 2017-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000500388
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000500388
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020170050000008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.32 n.5 2017
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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