DNA damage in wistar kyoto rats exercised during pregnancy

• Autor(a) principal: Corrêa, Mikaela da Silva [UNESP]
• Data de Publicação: 2017
• Outros Autores: Gelaleti, Rafael Bottaro [UNESP], Bento, Giovana Fernanda [UNESP], Damasceno, Débora Cristina [UNESP], Peraçoli, José Carlos [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/s0102-865020170050000008; http://hdl.handle.net/11449/174741
• topic: DNA damage; Exercise; Pregnancy; Rats

Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage. Results: Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05). Conclusion: The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.