The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats

Detalhes bibliográficos
Autor(a) principal: Camargo,Cristina Pires
Data de Publicação: 2016
Outros Autores: Fernandes,Felipe Alexandre, Lee,Michel Hyo Mi, Silva,Luiza Campos Moreira, Besteiro,Julio Morais, Gemperli,Rolf
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720
Resumo: ABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
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spelling The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in ratsSurgical FlapsBotulinum ToxinsType ASurvivalTobaccoRatsABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720Acta Cirúrgica Brasileira v.31 n.11 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020160110000003info:eu-repo/semantics/openAccessCamargo,Cristina PiresFernandes,Felipe AlexandreLee,Michel Hyo MiSilva,Luiza Campos MoreiraBesteiro,Julio MoraisGemperli,Rolfeng2016-12-05T00:00:00Zoai:scielo:S0102-86502016001100720Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2016-12-05T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
title The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
spellingShingle The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
Camargo,Cristina Pires
Surgical Flaps
Botulinum Toxins
Type A
Survival
Tobacco
Rats
title_short The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
title_full The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
title_fullStr The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
title_full_unstemmed The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
title_sort The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
author Camargo,Cristina Pires
author_facet Camargo,Cristina Pires
Fernandes,Felipe Alexandre
Lee,Michel Hyo Mi
Silva,Luiza Campos Moreira
Besteiro,Julio Morais
Gemperli,Rolf
author_role author
author2 Fernandes,Felipe Alexandre
Lee,Michel Hyo Mi
Silva,Luiza Campos Moreira
Besteiro,Julio Morais
Gemperli,Rolf
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Camargo,Cristina Pires
Fernandes,Felipe Alexandre
Lee,Michel Hyo Mi
Silva,Luiza Campos Moreira
Besteiro,Julio Morais
Gemperli,Rolf
dc.subject.por.fl_str_mv Surgical Flaps
Botulinum Toxins
Type A
Survival
Tobacco
Rats
topic Surgical Flaps
Botulinum Toxins
Type A
Survival
Tobacco
Rats
description ABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020160110000003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.31 n.11 2016
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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