The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720 |
Resumo: | ABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months. |
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Acta Cirúrgica Brasileira (Online) |
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The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in ratsSurgical FlapsBotulinum ToxinsType ASurvivalTobaccoRatsABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720Acta Cirúrgica Brasileira v.31 n.11 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020160110000003info:eu-repo/semantics/openAccessCamargo,Cristina PiresFernandes,Felipe AlexandreLee,Michel Hyo MiSilva,Luiza Campos MoreiraBesteiro,Julio MoraisGemperli,Rolfeng2016-12-05T00:00:00Zoai:scielo:S0102-86502016001100720Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2016-12-05T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
title |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
spellingShingle |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats Camargo,Cristina Pires Surgical Flaps Botulinum Toxins Type A Survival Tobacco Rats |
title_short |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
title_full |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
title_fullStr |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
title_full_unstemmed |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
title_sort |
The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats |
author |
Camargo,Cristina Pires |
author_facet |
Camargo,Cristina Pires Fernandes,Felipe Alexandre Lee,Michel Hyo Mi Silva,Luiza Campos Moreira Besteiro,Julio Morais Gemperli,Rolf |
author_role |
author |
author2 |
Fernandes,Felipe Alexandre Lee,Michel Hyo Mi Silva,Luiza Campos Moreira Besteiro,Julio Morais Gemperli,Rolf |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Camargo,Cristina Pires Fernandes,Felipe Alexandre Lee,Michel Hyo Mi Silva,Luiza Campos Moreira Besteiro,Julio Morais Gemperli,Rolf |
dc.subject.por.fl_str_mv |
Surgical Flaps Botulinum Toxins Type A Survival Tobacco Rats |
topic |
Surgical Flaps Botulinum Toxins Type A Survival Tobacco Rats |
description |
ABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001100720 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020160110000003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.31 n.11 2016 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126444038782976 |