Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

Detalhes bibliográficos
Autor(a) principal: Menezes,Honório Sampaio
Data de Publicação: 2009
Outros Autores: Zettler,Cláudio Galeano, Calone,Alice, Corrêa,Jackson Borges, Bartuscheck,Carla, Costa,Cristine Sortica da, Cirino,Sílvia Letícia Merceo Bacchi, Zielinsky,Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400002
Resumo: PURPOSE: To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). METHODS: Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar rats, bearing 50 rats, made up the control group. Morphometric data were obtained using a scale for the weight, length, heart and body measurements. Morphometric cellular data were obtained by a computer assisted method applied to the measurements of myocytes. Statistical analysis utilized Student's t-test, ANOVA and Levene test. RESULTS: Control offspring had greater mean body weight and length than offspring of diabetic rats (p < 0.001). Heart weight and length and heart-to-body ratios of newborn rats differed between groups at birth (p < 0.001), but showed no difference at 21 days. Mean nuclei area and perimetric value of the myocytes decrees throughout the first 21 days of life (p < 0.01) in the diabetic group. CONCLUSIONS: Heart hypertrophy on the offspring of diabetic rats at birth was demonstrated by the significant difference between the groups. After the eleventh day, no difference was found, which confirmed regression of cardiomegaly. The significant difference between the first and the 21th day of life, for nuclei area feature, demonstrate regression of cardiac hypertrophy in the offspring of diabetic rats.
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spelling Regression of gestational diabetes induced cardiomegaly in offspring of diabetic ratDiabetes, GestationalCardiomyopathy, HypertrophicRatsPURPOSE: To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). METHODS: Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar rats, bearing 50 rats, made up the control group. Morphometric data were obtained using a scale for the weight, length, heart and body measurements. Morphometric cellular data were obtained by a computer assisted method applied to the measurements of myocytes. Statistical analysis utilized Student's t-test, ANOVA and Levene test. RESULTS: Control offspring had greater mean body weight and length than offspring of diabetic rats (p < 0.001). Heart weight and length and heart-to-body ratios of newborn rats differed between groups at birth (p < 0.001), but showed no difference at 21 days. Mean nuclei area and perimetric value of the myocytes decrees throughout the first 21 days of life (p < 0.01) in the diabetic group. CONCLUSIONS: Heart hypertrophy on the offspring of diabetic rats at birth was demonstrated by the significant difference between the groups. After the eleventh day, no difference was found, which confirmed regression of cardiomegaly. The significant difference between the first and the 21th day of life, for nuclei area feature, demonstrate regression of cardiac hypertrophy in the offspring of diabetic rats.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400002Acta Cirúrgica Brasileira v.24 n.4 2009reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502009000400002info:eu-repo/semantics/openAccessMenezes,Honório SampaioZettler,Cláudio GaleanoCalone,AliceCorrêa,Jackson BorgesBartuscheck,CarlaCosta,Cristine Sortica daCirino,Sílvia Letícia Merceo BacchiZielinsky,Pauloeng2009-08-17T00:00:00Zoai:scielo:S0102-86502009000400002Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2009-08-17T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
title Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
spellingShingle Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
Menezes,Honório Sampaio
Diabetes, Gestational
Cardiomyopathy, Hypertrophic
Rats
title_short Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
title_full Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
title_fullStr Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
title_full_unstemmed Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
title_sort Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat
author Menezes,Honório Sampaio
author_facet Menezes,Honório Sampaio
Zettler,Cláudio Galeano
Calone,Alice
Corrêa,Jackson Borges
Bartuscheck,Carla
Costa,Cristine Sortica da
Cirino,Sílvia Letícia Merceo Bacchi
Zielinsky,Paulo
author_role author
author2 Zettler,Cláudio Galeano
Calone,Alice
Corrêa,Jackson Borges
Bartuscheck,Carla
Costa,Cristine Sortica da
Cirino,Sílvia Letícia Merceo Bacchi
Zielinsky,Paulo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Menezes,Honório Sampaio
Zettler,Cláudio Galeano
Calone,Alice
Corrêa,Jackson Borges
Bartuscheck,Carla
Costa,Cristine Sortica da
Cirino,Sílvia Letícia Merceo Bacchi
Zielinsky,Paulo
dc.subject.por.fl_str_mv Diabetes, Gestational
Cardiomyopathy, Hypertrophic
Rats
topic Diabetes, Gestational
Cardiomyopathy, Hypertrophic
Rats
description PURPOSE: To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). METHODS: Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar rats, bearing 50 rats, made up the control group. Morphometric data were obtained using a scale for the weight, length, heart and body measurements. Morphometric cellular data were obtained by a computer assisted method applied to the measurements of myocytes. Statistical analysis utilized Student's t-test, ANOVA and Levene test. RESULTS: Control offspring had greater mean body weight and length than offspring of diabetic rats (p < 0.001). Heart weight and length and heart-to-body ratios of newborn rats differed between groups at birth (p < 0.001), but showed no difference at 21 days. Mean nuclei area and perimetric value of the myocytes decrees throughout the first 21 days of life (p < 0.01) in the diabetic group. CONCLUSIONS: Heart hypertrophy on the offspring of diabetic rats at birth was demonstrated by the significant difference between the groups. After the eleventh day, no difference was found, which confirmed regression of cardiomegaly. The significant difference between the first and the 21th day of life, for nuclei area feature, demonstrate regression of cardiac hypertrophy in the offspring of diabetic rats.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000400002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502009000400002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.24 n.4 2009
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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