Tadalafil protector effect during ischemia-reperfusion in rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973 |
Resumo: | Abstract Purpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium. |
id |
SBDPC-1_29e0f2862f788da6635cf0beab5dc225 |
---|---|
oai_identifier_str |
oai:scielo:S0102-86502017001100973 |
network_acronym_str |
SBDPC-1 |
network_name_str |
Acta Cirúrgica Brasileira (Online) |
repository_id_str |
|
spelling |
Tadalafil protector effect during ischemia-reperfusion in ratsTadalafilReperfusion InjuryIschemiaKidneyRats.Abstract Purpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973Acta Cirúrgica Brasileira v.32 n.11 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170110000009info:eu-repo/semantics/openAccessWietzikoski,Eduardo Gabriel GerberFoiatto,Julio CesarCzeczko,Nicolau GregoriMalafaia,OsvaldoKoleski,Fernando CesarMierzwa,Tiago CesarGomes,Regina de Paula Xaviereng2017-12-19T00:00:00Zoai:scielo:S0102-86502017001100973Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-12-19T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Tadalafil protector effect during ischemia-reperfusion in rats |
title |
Tadalafil protector effect during ischemia-reperfusion in rats |
spellingShingle |
Tadalafil protector effect during ischemia-reperfusion in rats Wietzikoski,Eduardo Gabriel Gerber Tadalafil Reperfusion Injury Ischemia Kidney Rats. |
title_short |
Tadalafil protector effect during ischemia-reperfusion in rats |
title_full |
Tadalafil protector effect during ischemia-reperfusion in rats |
title_fullStr |
Tadalafil protector effect during ischemia-reperfusion in rats |
title_full_unstemmed |
Tadalafil protector effect during ischemia-reperfusion in rats |
title_sort |
Tadalafil protector effect during ischemia-reperfusion in rats |
author |
Wietzikoski,Eduardo Gabriel Gerber |
author_facet |
Wietzikoski,Eduardo Gabriel Gerber Foiatto,Julio Cesar Czeczko,Nicolau Gregori Malafaia,Osvaldo Koleski,Fernando Cesar Mierzwa,Tiago Cesar Gomes,Regina de Paula Xavier |
author_role |
author |
author2 |
Foiatto,Julio Cesar Czeczko,Nicolau Gregori Malafaia,Osvaldo Koleski,Fernando Cesar Mierzwa,Tiago Cesar Gomes,Regina de Paula Xavier |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Wietzikoski,Eduardo Gabriel Gerber Foiatto,Julio Cesar Czeczko,Nicolau Gregori Malafaia,Osvaldo Koleski,Fernando Cesar Mierzwa,Tiago Cesar Gomes,Regina de Paula Xavier |
dc.subject.por.fl_str_mv |
Tadalafil Reperfusion Injury Ischemia Kidney Rats. |
topic |
Tadalafil Reperfusion Injury Ischemia Kidney Rats. |
description |
Abstract Purpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020170110000009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.32 n.11 2017 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126444543148032 |