Tadalafil protector effect during ischemia-reperfusion in rats

Detalhes bibliográficos
Autor(a) principal: Wietzikoski,Eduardo Gabriel Gerber
Data de Publicação: 2017
Outros Autores: Foiatto,Julio Cesar, Czeczko,Nicolau Gregori, Malafaia,Osvaldo, Koleski,Fernando Cesar, Mierzwa,Tiago Cesar, Gomes,Regina de Paula Xavier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973
Resumo: Abstract Purpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium.
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spelling Tadalafil protector effect during ischemia-reperfusion in ratsTadalafilReperfusion InjuryIschemiaKidneyRats.Abstract Purpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973Acta Cirúrgica Brasileira v.32 n.11 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170110000009info:eu-repo/semantics/openAccessWietzikoski,Eduardo Gabriel GerberFoiatto,Julio CesarCzeczko,Nicolau GregoriMalafaia,OsvaldoKoleski,Fernando CesarMierzwa,Tiago CesarGomes,Regina de Paula Xaviereng2017-12-19T00:00:00Zoai:scielo:S0102-86502017001100973Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-12-19T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Tadalafil protector effect during ischemia-reperfusion in rats
title Tadalafil protector effect during ischemia-reperfusion in rats
spellingShingle Tadalafil protector effect during ischemia-reperfusion in rats
Wietzikoski,Eduardo Gabriel Gerber
Tadalafil
Reperfusion Injury
Ischemia
Kidney
Rats.
title_short Tadalafil protector effect during ischemia-reperfusion in rats
title_full Tadalafil protector effect during ischemia-reperfusion in rats
title_fullStr Tadalafil protector effect during ischemia-reperfusion in rats
title_full_unstemmed Tadalafil protector effect during ischemia-reperfusion in rats
title_sort Tadalafil protector effect during ischemia-reperfusion in rats
author Wietzikoski,Eduardo Gabriel Gerber
author_facet Wietzikoski,Eduardo Gabriel Gerber
Foiatto,Julio Cesar
Czeczko,Nicolau Gregori
Malafaia,Osvaldo
Koleski,Fernando Cesar
Mierzwa,Tiago Cesar
Gomes,Regina de Paula Xavier
author_role author
author2 Foiatto,Julio Cesar
Czeczko,Nicolau Gregori
Malafaia,Osvaldo
Koleski,Fernando Cesar
Mierzwa,Tiago Cesar
Gomes,Regina de Paula Xavier
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wietzikoski,Eduardo Gabriel Gerber
Foiatto,Julio Cesar
Czeczko,Nicolau Gregori
Malafaia,Osvaldo
Koleski,Fernando Cesar
Mierzwa,Tiago Cesar
Gomes,Regina de Paula Xavier
dc.subject.por.fl_str_mv Tadalafil
Reperfusion Injury
Ischemia
Kidney
Rats.
topic Tadalafil
Reperfusion Injury
Ischemia
Kidney
Rats.
description Abstract Purpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017001100973
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020170110000009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.32 n.11 2017
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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