C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000700203 |
Resumo: | Abstract Purpose Studies have demonstrated that star fruit consumption by nephropathic patients triggers severe neurotoxic effects that can lead to convulsions or even death. Brain areas likely susceptible to star fruit poisoning have not been investigated. The objective of the present study was to map possible epileptogenic areas susceptible to star fruit intoxication in nephropathic rats. Methods The study analyzed 25 rats (5 groups). Rats in the experimental group underwent bilateral ureteral obstruction surgery and orogastric gavages with star fruit juice. An electroencephalogram was used to confirm convulsive seizures. Urea and creatinine levels were used to confirm the uremia model. Immunohistochemical analysis was used to map cells with c-Fos protein (c-Fos+ cells) to identify brain areas with increased neuronal activity. Control groups included non-nephropathic and nephropathic rats that did not receive star fruit. Results A statistically significant increase (p<0.01) in c-Fos+ cells was noted in nephropathic animals receiving star fruit juice compared to control groups, in brain areas commonly related to epileptogenic neural circuits including the hippocampus, amygdala, rhinal cortex, anterior cingulate area, piriform area, and medial dorsal thalamus. Conclusion These data corroborate the neurotoxic capacity of star fruit in nephropathic patients. |
id |
SBDPC-1_2a1f4d99506d35daa16d51d85dbe4b2a |
---|---|
oai_identifier_str |
oai:scielo:S0102-86502020000700203 |
network_acronym_str |
SBDPC-1 |
network_name_str |
Acta Cirúrgica Brasileira (Online) |
repository_id_str |
|
spelling |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoningAverrhoaSeizuresKidney DiseasesNeurotoxicity SyndromesRatsAbstract Purpose Studies have demonstrated that star fruit consumption by nephropathic patients triggers severe neurotoxic effects that can lead to convulsions or even death. Brain areas likely susceptible to star fruit poisoning have not been investigated. The objective of the present study was to map possible epileptogenic areas susceptible to star fruit intoxication in nephropathic rats. Methods The study analyzed 25 rats (5 groups). Rats in the experimental group underwent bilateral ureteral obstruction surgery and orogastric gavages with star fruit juice. An electroencephalogram was used to confirm convulsive seizures. Urea and creatinine levels were used to confirm the uremia model. Immunohistochemical analysis was used to map cells with c-Fos protein (c-Fos+ cells) to identify brain areas with increased neuronal activity. Control groups included non-nephropathic and nephropathic rats that did not receive star fruit. Results A statistically significant increase (p<0.01) in c-Fos+ cells was noted in nephropathic animals receiving star fruit juice compared to control groups, in brain areas commonly related to epileptogenic neural circuits including the hippocampus, amygdala, rhinal cortex, anterior cingulate area, piriform area, and medial dorsal thalamus. Conclusion These data corroborate the neurotoxic capacity of star fruit in nephropathic patients.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000700203Acta Cirúrgica Brasileira v.35 n.7 2020reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020200070000005info:eu-repo/semantics/openAccessSantana,Renato FigueiredoSilva,Layla Alves Rodrigues daAchar,EduardoBallester,GersonRibeiro Junior,Marcelo Augusto FontenelleOrtiz,Sandra Regina Motaeng2020-08-06T00:00:00Zoai:scielo:S0102-86502020000700203Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2020-08-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning |
title |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning |
spellingShingle |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning Santana,Renato Figueiredo Averrhoa Seizures Kidney Diseases Neurotoxicity Syndromes Rats |
title_short |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning |
title_full |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning |
title_fullStr |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning |
title_full_unstemmed |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning |
title_sort |
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning |
author |
Santana,Renato Figueiredo |
author_facet |
Santana,Renato Figueiredo Silva,Layla Alves Rodrigues da Achar,Eduardo Ballester,Gerson Ribeiro Junior,Marcelo Augusto Fontenelle Ortiz,Sandra Regina Mota |
author_role |
author |
author2 |
Silva,Layla Alves Rodrigues da Achar,Eduardo Ballester,Gerson Ribeiro Junior,Marcelo Augusto Fontenelle Ortiz,Sandra Regina Mota |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santana,Renato Figueiredo Silva,Layla Alves Rodrigues da Achar,Eduardo Ballester,Gerson Ribeiro Junior,Marcelo Augusto Fontenelle Ortiz,Sandra Regina Mota |
dc.subject.por.fl_str_mv |
Averrhoa Seizures Kidney Diseases Neurotoxicity Syndromes Rats |
topic |
Averrhoa Seizures Kidney Diseases Neurotoxicity Syndromes Rats |
description |
Abstract Purpose Studies have demonstrated that star fruit consumption by nephropathic patients triggers severe neurotoxic effects that can lead to convulsions or even death. Brain areas likely susceptible to star fruit poisoning have not been investigated. The objective of the present study was to map possible epileptogenic areas susceptible to star fruit intoxication in nephropathic rats. Methods The study analyzed 25 rats (5 groups). Rats in the experimental group underwent bilateral ureteral obstruction surgery and orogastric gavages with star fruit juice. An electroencephalogram was used to confirm convulsive seizures. Urea and creatinine levels were used to confirm the uremia model. Immunohistochemical analysis was used to map cells with c-Fos protein (c-Fos+ cells) to identify brain areas with increased neuronal activity. Control groups included non-nephropathic and nephropathic rats that did not receive star fruit. Results A statistically significant increase (p<0.01) in c-Fos+ cells was noted in nephropathic animals receiving star fruit juice compared to control groups, in brain areas commonly related to epileptogenic neural circuits including the hippocampus, amygdala, rhinal cortex, anterior cingulate area, piriform area, and medial dorsal thalamus. Conclusion These data corroborate the neurotoxic capacity of star fruit in nephropathic patients. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000700203 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502020000700203 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020200070000005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.35 n.7 2020 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126445826605056 |