Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000200202 |
Resumo: | ABSTRACT Purpose To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. Methods Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. Results To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. Conclusions The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process. |
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Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathyAverrhoaSeizuresKidney DiseasesElectroencephalographyRatsABSTRACT Purpose To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. Methods Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. Results To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. Conclusions The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000200202Acta Cirúrgica Brasileira v.36 n.2 2021reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/acb360204info:eu-repo/semantics/openAccessSilva,Layla Alves Rodrigues daSantana,Renato FigueiredoAchar,EduardoBallester,GersonOrtiz,Sandra Regina MotaRibeiro Junior,Marcelo Augusto Fontenelleeng2021-02-19T00:00:00Zoai:scielo:S0102-86502021000200202Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2021-02-19T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy |
title |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy |
spellingShingle |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy Silva,Layla Alves Rodrigues da Averrhoa Seizures Kidney Diseases Electroencephalography Rats |
title_short |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy |
title_full |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy |
title_fullStr |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy |
title_full_unstemmed |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy |
title_sort |
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy |
author |
Silva,Layla Alves Rodrigues da |
author_facet |
Silva,Layla Alves Rodrigues da Santana,Renato Figueiredo Achar,Eduardo Ballester,Gerson Ortiz,Sandra Regina Mota Ribeiro Junior,Marcelo Augusto Fontenelle |
author_role |
author |
author2 |
Santana,Renato Figueiredo Achar,Eduardo Ballester,Gerson Ortiz,Sandra Regina Mota Ribeiro Junior,Marcelo Augusto Fontenelle |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Layla Alves Rodrigues da Santana,Renato Figueiredo Achar,Eduardo Ballester,Gerson Ortiz,Sandra Regina Mota Ribeiro Junior,Marcelo Augusto Fontenelle |
dc.subject.por.fl_str_mv |
Averrhoa Seizures Kidney Diseases Electroencephalography Rats |
topic |
Averrhoa Seizures Kidney Diseases Electroencephalography Rats |
description |
ABSTRACT Purpose To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. Methods Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. Results To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. Conclusions The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000200202 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000200202 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/acb360204 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.36 n.2 2021 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
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1752126445928316928 |