Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000500203 |
Resumo: | ABSTRACT Purpose As a classical xenotransplantation model, porcine kidneys have been transplanted into the lower abdomen of non-human primates. However, we have improved upon this model by using size-matched grafting in the orthotopic position. The beneficial aspects and surgical details of our method are reported herein. Methods Donors were two newborn pigs (weighting 5 to 6 kg) and recipients were two cynomolgus monkeys (weighting, approximately, 7 kg). After bilateral nephrectomy, kidneys were cold-transported in Euro-Collins solution. The porcine kidney was transplanted to the site of a left nephrectomy and fixed to the peritoneum. Results Kidneys transplanted to the lower abdomen by the conventional method were more susceptible to torsion of the renal vein (two cases). In contrast, early-stage blood flow insufficiency did not occur in orthotopic transplants of theleft kidney. Conclusions Size-matched porcine-primate renal grafting using our method of transplanting tothe natural position of the kidneys contributes to stable post-transplant blood flow to the kidney. |
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Acta Cirúrgica Brasileira (Online) |
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Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipientsKidney TransplantationSurgerySwinePrimatesABSTRACT Purpose As a classical xenotransplantation model, porcine kidneys have been transplanted into the lower abdomen of non-human primates. However, we have improved upon this model by using size-matched grafting in the orthotopic position. The beneficial aspects and surgical details of our method are reported herein. Methods Donors were two newborn pigs (weighting 5 to 6 kg) and recipients were two cynomolgus monkeys (weighting, approximately, 7 kg). After bilateral nephrectomy, kidneys were cold-transported in Euro-Collins solution. The porcine kidney was transplanted to the site of a left nephrectomy and fixed to the peritoneum. Results Kidneys transplanted to the lower abdomen by the conventional method were more susceptible to torsion of the renal vein (two cases). In contrast, early-stage blood flow insufficiency did not occur in orthotopic transplants of theleft kidney. Conclusions Size-matched porcine-primate renal grafting using our method of transplanting tothe natural position of the kidneys contributes to stable post-transplant blood flow to the kidney.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000500203Acta Cirúrgica Brasileira v.36 n.5 2021reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/acb360503info:eu-repo/semantics/openAccessTakamura,TsuyoshiSasaki,HiroshiHirayama,HaruyukiKiyoshi,AkihikoInoue,MakotoMatsui,KenjiMatsumoto,NaotoSaito,YatsumuFujimoto,ToshinariTajiri,SusumuYamanaka,ShuichiroMatsumoto,KeiMiyawaki,TakeshiYokoo,TakashiKobayashi,Eijieng2021-06-16T00:00:00Zoai:scielo:S0102-86502021000500203Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2021-06-16T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients |
title |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients |
spellingShingle |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients Takamura,Tsuyoshi Kidney Transplantation Surgery Swine Primates |
title_short |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients |
title_full |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients |
title_fullStr |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients |
title_full_unstemmed |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients |
title_sort |
Techniques of orthotopic renal transplantation. II. Size-matched porcine grafts in monkey recipients |
author |
Takamura,Tsuyoshi |
author_facet |
Takamura,Tsuyoshi Sasaki,Hiroshi Hirayama,Haruyuki Kiyoshi,Akihiko Inoue,Makoto Matsui,Kenji Matsumoto,Naoto Saito,Yatsumu Fujimoto,Toshinari Tajiri,Susumu Yamanaka,Shuichiro Matsumoto,Kei Miyawaki,Takeshi Yokoo,Takashi Kobayashi,Eiji |
author_role |
author |
author2 |
Sasaki,Hiroshi Hirayama,Haruyuki Kiyoshi,Akihiko Inoue,Makoto Matsui,Kenji Matsumoto,Naoto Saito,Yatsumu Fujimoto,Toshinari Tajiri,Susumu Yamanaka,Shuichiro Matsumoto,Kei Miyawaki,Takeshi Yokoo,Takashi Kobayashi,Eiji |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Takamura,Tsuyoshi Sasaki,Hiroshi Hirayama,Haruyuki Kiyoshi,Akihiko Inoue,Makoto Matsui,Kenji Matsumoto,Naoto Saito,Yatsumu Fujimoto,Toshinari Tajiri,Susumu Yamanaka,Shuichiro Matsumoto,Kei Miyawaki,Takeshi Yokoo,Takashi Kobayashi,Eiji |
dc.subject.por.fl_str_mv |
Kidney Transplantation Surgery Swine Primates |
topic |
Kidney Transplantation Surgery Swine Primates |
description |
ABSTRACT Purpose As a classical xenotransplantation model, porcine kidneys have been transplanted into the lower abdomen of non-human primates. However, we have improved upon this model by using size-matched grafting in the orthotopic position. The beneficial aspects and surgical details of our method are reported herein. Methods Donors were two newborn pigs (weighting 5 to 6 kg) and recipients were two cynomolgus monkeys (weighting, approximately, 7 kg). After bilateral nephrectomy, kidneys were cold-transported in Euro-Collins solution. The porcine kidney was transplanted to the site of a left nephrectomy and fixed to the peritoneum. Results Kidneys transplanted to the lower abdomen by the conventional method were more susceptible to torsion of the renal vein (two cases). In contrast, early-stage blood flow insufficiency did not occur in orthotopic transplants of theleft kidney. Conclusions Size-matched porcine-primate renal grafting using our method of transplanting tothe natural position of the kidneys contributes to stable post-transplant blood flow to the kidney. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000500203 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000500203 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/acb360503 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.36 n.5 2021 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126446231355392 |