Bone repair process in calvarial defects using bioactive glass and calcium sulfate barrier

• Autor(a) principal: Silveira,Roger Lanes
• Data de Publicação: 2008
• Outros Autores: Machado,Rosilene Andréa, Silveira,Carla Roberta de Siqueira, Oliveira,Rogério Belle
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400005
• topic: Bone Substitutes; Bone Regeneration; Calcium Sulfate; Skull; Rats

PURPOSE: To analyze bone repair process in Wistar rats' calvaria, with the use of two different biomaterials. METHODS: Forty two male Wistar rats were used, and four bicortical cranial cavities were created in each animal. The cavities were filled with: bioactive glass (BG); calcium sulfate barrier (CSB); bioactive glass covered with calcium sulfate barrier (BG/CSB); and autogenous blood clot (control). The animals were euthanized 7, 14, 21, 30, 60, 90, e 120 days after surgery. The scalps were removed and submitted to a routine process for histological preparation: staining with Haematoxylin and Eosin (HE). RESULTS: The BG was not completely resorbed; however, after 60 days, a decrease in size as well as a change in the morphological granule were observed. CSB was not observed in the last group (after 120 days). CONCLUSIONS: In Wistar rat calvaria bioactive glass, in an isolated form, negatively interfered in the bone repair process; the calcium sulfate barrier, in an isolated form, presented the capacity to maintain space, allowing the flow of osteogenic cells; the bioactive glass covered with calcium sulfate barrier association presented a better osteoconductive capacity when compared to isolated materials; calcium sulfate barrier was completely resorbed after 90 days; control cavities did not completely heal until 120 days after surgery.