Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000009 |
Resumo: | PURPOSE: To investigate the differences in Langerhans cells (LCs) populations between HIV-positive and negative anal squamous cell carcinomas patients. METHODS: Twenty five patients (14 HIV-positive and 11 HIV-negative) were evaluated. Paraffin-block transversal thin sections from biopsies of anal squamous cell carcinomas (ASCC) were stained using the anti-CD1A antibody that identifies activated LCs. LCs counts were performed using histometry at 20 different sites, at baseline in the ASCC cases. These were then compared with LCs counts in anal canal specimens from HIV-negative and positive patients without ASCC (controls groups). RESULTS: In patients with ASCC, the LC count was greater among HIV-negative individuals than among HIV-positive individuals (p<0.05). The LC count was greater in the control HIV-negative group than in HIV-positive patients with ASCC (p<0.05). CONCLUSION: There was a lower amount of activated LCs in HIV-positive patients with anal squamous cell carcinomas than in HIV-negative patients, thereby suggesting worsening of the immune response. |
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Acta Cirúrgica Brasileira (Online) |
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Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patientsAcquired Immunodeficiency SyndromeCarcinoma, Squamous CellAnal CanalHIVLangerhans CellsPURPOSE: To investigate the differences in Langerhans cells (LCs) populations between HIV-positive and negative anal squamous cell carcinomas patients. METHODS: Twenty five patients (14 HIV-positive and 11 HIV-negative) were evaluated. Paraffin-block transversal thin sections from biopsies of anal squamous cell carcinomas (ASCC) were stained using the anti-CD1A antibody that identifies activated LCs. LCs counts were performed using histometry at 20 different sites, at baseline in the ASCC cases. These were then compared with LCs counts in anal canal specimens from HIV-negative and positive patients without ASCC (controls groups). RESULTS: In patients with ASCC, the LC count was greater among HIV-negative individuals than among HIV-positive individuals (p<0.05). The LC count was greater in the control HIV-negative group than in HIV-positive patients with ASCC (p<0.05). CONCLUSION: There was a lower amount of activated LCs in HIV-positive patients with anal squamous cell carcinomas than in HIV-negative patients, thereby suggesting worsening of the immune response.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000009Acta Cirúrgica Brasileira v.27 n.10 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012001000009info:eu-repo/semantics/openAccessCruz,Sylvia Heloisa ArantesNadal,Sidney RobertoNadal,Carmen Ruth ManzioneCalore,Edenilson Eduardoeng2012-09-27T00:00:00Zoai:scielo:S0102-86502012001000009Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-09-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
spellingShingle |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients Cruz,Sylvia Heloisa Arantes Acquired Immunodeficiency Syndrome Carcinoma, Squamous Cell Anal Canal HIV Langerhans Cells |
title_short |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_full |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_fullStr |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_full_unstemmed |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
title_sort |
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients |
author |
Cruz,Sylvia Heloisa Arantes |
author_facet |
Cruz,Sylvia Heloisa Arantes Nadal,Sidney Roberto Nadal,Carmen Ruth Manzione Calore,Edenilson Eduardo |
author_role |
author |
author2 |
Nadal,Sidney Roberto Nadal,Carmen Ruth Manzione Calore,Edenilson Eduardo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cruz,Sylvia Heloisa Arantes Nadal,Sidney Roberto Nadal,Carmen Ruth Manzione Calore,Edenilson Eduardo |
dc.subject.por.fl_str_mv |
Acquired Immunodeficiency Syndrome Carcinoma, Squamous Cell Anal Canal HIV Langerhans Cells |
topic |
Acquired Immunodeficiency Syndrome Carcinoma, Squamous Cell Anal Canal HIV Langerhans Cells |
description |
PURPOSE: To investigate the differences in Langerhans cells (LCs) populations between HIV-positive and negative anal squamous cell carcinomas patients. METHODS: Twenty five patients (14 HIV-positive and 11 HIV-negative) were evaluated. Paraffin-block transversal thin sections from biopsies of anal squamous cell carcinomas (ASCC) were stained using the anti-CD1A antibody that identifies activated LCs. LCs counts were performed using histometry at 20 different sites, at baseline in the ASCC cases. These were then compared with LCs counts in anal canal specimens from HIV-negative and positive patients without ASCC (controls groups). RESULTS: In patients with ASCC, the LC count was greater among HIV-negative individuals than among HIV-positive individuals (p<0.05). The LC count was greater in the control HIV-negative group than in HIV-positive patients with ASCC (p<0.05). CONCLUSION: There was a lower amount of activated LCs in HIV-positive patients with anal squamous cell carcinomas than in HIV-negative patients, thereby suggesting worsening of the immune response. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502012001000009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.27 n.10 2012 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126441347088384 |