Myocardial protection by continuous, blood, antegrade-retrograde cardioplegia in rabbits

• Autor(a) principal: Martins,Antônio Sérgio
• Data de Publicação: 2007
• Outros Autores: Silva,Marcos Augusto de Moraes, Padovani,Carlos Roberto, Matsubara,Beatriz Boljokian, Braile,Domingo Marcolino, Catâneo,Antonio José Maria
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000100008
• topic: Ventricular Function; Ischemia; Myocardium; Animal, Models; Heart Arrest, Induced; Rabbits

PURPOSE: To study the effectiveness of the continuous, blood, antegrade-retrograde cardioplegia in an experimental model of isolated heart, evaluating ventricular function. METHODS: Rabbits were divided into four groups: Control-C(n=10); ischemic crystalloid cardioplegia-IC(n=10); ischemic blood cardioplegia-IB(n=10); ischemic non cardioplegia-INC(n=10). After the ischemic protocol period the ventricular function was analyzed by the intra-ventricular balloon technique. RESULTS: the intra-ventricular developed pressure (IVDP) was: C(92.90±6.86mmHg); IC(77.78±6.15mmHg); IB(93.64±5.09mmHg); INC(39.46 ±8.91mmHg) p<0.005. The first derivative of intra-ventricular pressure in its positive deflection was: C(1137.50± 92.23mmHg/sec); IC(1130.62 ±43.78mmHg/sec); IB(1187.58± 88.38mmHg/sec); INC(620.02± 43.80mmHg/se) p<0.005. The first derivate pressure in its negative deflection was: C(770.00± 73.41mmHg/sec); IC(610.03 ±47.43mmg/sec); IB(762.53 ±46.02mmHg/sec); INC(412.35 ±84.36mmHg/sec) p<0,005. The stress-strain angular logarithmic coefficient was: C(0.108± 0.02); IC(0.159± 0.038); IB(0.114 ±0.016); INC(0.175± 0.038) p<0.05. CONCLUSION: The ischemic group protected by blood cardioplegia showed better ventricular function than ischemic group protected by crystalloid cardioplegia and the non protected group.