Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model

Detalhes bibliográficos
Autor(a) principal: Teixeira,Antonio Roberto Franchi
Data de Publicação: 2008
Outros Autores: Molan,Nilza Trindade, Bellodi-Privato,Marta, Coelho,Ana Maria, Leite,Kátia Ramos, Seguro,Antônio Carlos, Bacchella,Telésforo, Machado,Marcel Cerqueira César
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400013
Resumo: PURPOSE: To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats. METHODS: Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification. RESULTS: There were no statistical differences between groups for all analysed parameters. CONCLUSION: In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.
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spelling Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat modelIschemiaReperfusionLiverRatsPURPOSE: To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats. METHODS: Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification. RESULTS: There were no statistical differences between groups for all analysed parameters. CONCLUSION: In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400013Acta Cirúrgica Brasileira v.23 n.4 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000400013info:eu-repo/semantics/openAccessTeixeira,Antonio Roberto FranchiMolan,Nilza TrindadeBellodi-Privato,MartaCoelho,Ana MariaLeite,Kátia RamosSeguro,Antônio CarlosBacchella,TelésforoMachado,Marcel Cerqueira Césareng2008-07-15T00:00:00Zoai:scielo:S0102-86502008000400013Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-07-15T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
title Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
spellingShingle Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
Teixeira,Antonio Roberto Franchi
Ischemia
Reperfusion
Liver
Rats
title_short Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
title_full Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
title_fullStr Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
title_full_unstemmed Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
title_sort Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
author Teixeira,Antonio Roberto Franchi
author_facet Teixeira,Antonio Roberto Franchi
Molan,Nilza Trindade
Bellodi-Privato,Marta
Coelho,Ana Maria
Leite,Kátia Ramos
Seguro,Antônio Carlos
Bacchella,Telésforo
Machado,Marcel Cerqueira César
author_role author
author2 Molan,Nilza Trindade
Bellodi-Privato,Marta
Coelho,Ana Maria
Leite,Kátia Ramos
Seguro,Antônio Carlos
Bacchella,Telésforo
Machado,Marcel Cerqueira César
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira,Antonio Roberto Franchi
Molan,Nilza Trindade
Bellodi-Privato,Marta
Coelho,Ana Maria
Leite,Kátia Ramos
Seguro,Antônio Carlos
Bacchella,Telésforo
Machado,Marcel Cerqueira César
dc.subject.por.fl_str_mv Ischemia
Reperfusion
Liver
Rats
topic Ischemia
Reperfusion
Liver
Rats
description PURPOSE: To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats. METHODS: Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification. RESULTS: There were no statistical differences between groups for all analysed parameters. CONCLUSION: In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.
publishDate 2008
dc.date.none.fl_str_mv 2008-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502008000400013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.23 n.4 2008
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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