Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats

Detalhes bibliográficos
Autor(a) principal: Ebertz,Claudia Emanuelli
Data de Publicação: 2014
Outros Autores: Bonfleur,Maria Lúcia, Bertasso,Iala Milene, Mendes,Mariana Carla, Lubaczeuski,Camila, Araujo,Allan Cezar de Freitas, Paes,Antônio Marcus, Amorim,Elaine Manoela Porto de, Balbo,Sandra Lucinei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609
Resumo: PURPOSE:To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.
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spelling Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese ratsJejunoileal BypassFatty LiverObesityRatsPURPOSE:To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609Acta Cirúrgica Brasileira v.29 n.9 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-8650201400150009info:eu-repo/semantics/openAccessEbertz,Claudia EmanuelliBonfleur,Maria LúciaBertasso,Iala MileneMendes,Mariana CarlaLubaczeuski,CamilaAraujo,Allan Cezar de FreitasPaes,Antônio MarcusAmorim,Elaine Manoela Porto deBalbo,Sandra Lucineieng2015-10-27T00:00:00Zoai:scielo:S0102-86502014000900609Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
title Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
spellingShingle Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
Ebertz,Claudia Emanuelli
Jejunoileal Bypass
Fatty Liver
Obesity
Rats
title_short Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
title_full Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
title_fullStr Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
title_full_unstemmed Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
title_sort Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
author Ebertz,Claudia Emanuelli
author_facet Ebertz,Claudia Emanuelli
Bonfleur,Maria Lúcia
Bertasso,Iala Milene
Mendes,Mariana Carla
Lubaczeuski,Camila
Araujo,Allan Cezar de Freitas
Paes,Antônio Marcus
Amorim,Elaine Manoela Porto de
Balbo,Sandra Lucinei
author_role author
author2 Bonfleur,Maria Lúcia
Bertasso,Iala Milene
Mendes,Mariana Carla
Lubaczeuski,Camila
Araujo,Allan Cezar de Freitas
Paes,Antônio Marcus
Amorim,Elaine Manoela Porto de
Balbo,Sandra Lucinei
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ebertz,Claudia Emanuelli
Bonfleur,Maria Lúcia
Bertasso,Iala Milene
Mendes,Mariana Carla
Lubaczeuski,Camila
Araujo,Allan Cezar de Freitas
Paes,Antônio Marcus
Amorim,Elaine Manoela Porto de
Balbo,Sandra Lucinei
dc.subject.por.fl_str_mv Jejunoileal Bypass
Fatty Liver
Obesity
Rats
topic Jejunoileal Bypass
Fatty Liver
Obesity
Rats
description PURPOSE:To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-8650201400150009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.29 n.9 2014
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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