Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609 |
Resumo: | PURPOSE:To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet. |
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Acta Cirúrgica Brasileira (Online) |
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Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese ratsJejunoileal BypassFatty LiverObesityRatsPURPOSE:To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609Acta Cirúrgica Brasileira v.29 n.9 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-8650201400150009info:eu-repo/semantics/openAccessEbertz,Claudia EmanuelliBonfleur,Maria LúciaBertasso,Iala MileneMendes,Mariana CarlaLubaczeuski,CamilaAraujo,Allan Cezar de FreitasPaes,Antônio MarcusAmorim,Elaine Manoela Porto deBalbo,Sandra Lucineieng2015-10-27T00:00:00Zoai:scielo:S0102-86502014000900609Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
title |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
spellingShingle |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats Ebertz,Claudia Emanuelli Jejunoileal Bypass Fatty Liver Obesity Rats |
title_short |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
title_full |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
title_fullStr |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
title_full_unstemmed |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
title_sort |
Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats |
author |
Ebertz,Claudia Emanuelli |
author_facet |
Ebertz,Claudia Emanuelli Bonfleur,Maria Lúcia Bertasso,Iala Milene Mendes,Mariana Carla Lubaczeuski,Camila Araujo,Allan Cezar de Freitas Paes,Antônio Marcus Amorim,Elaine Manoela Porto de Balbo,Sandra Lucinei |
author_role |
author |
author2 |
Bonfleur,Maria Lúcia Bertasso,Iala Milene Mendes,Mariana Carla Lubaczeuski,Camila Araujo,Allan Cezar de Freitas Paes,Antônio Marcus Amorim,Elaine Manoela Porto de Balbo,Sandra Lucinei |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ebertz,Claudia Emanuelli Bonfleur,Maria Lúcia Bertasso,Iala Milene Mendes,Mariana Carla Lubaczeuski,Camila Araujo,Allan Cezar de Freitas Paes,Antônio Marcus Amorim,Elaine Manoela Porto de Balbo,Sandra Lucinei |
dc.subject.por.fl_str_mv |
Jejunoileal Bypass Fatty Liver Obesity Rats |
topic |
Jejunoileal Bypass Fatty Liver Obesity Rats |
description |
PURPOSE:To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900609 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-8650201400150009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.29 n.9 2014 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442668294144 |