Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL)
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600007 |
Resumo: | PURPOSE: Evaluation the hypoglycemic and healing effects of the Strychnos pseudoquina. METHODS: 33 Wistar rats were divided in the following groups, group 1 not sensitized with alloxan and untreated by aqueous extracts; group 2 sensitized with aloxana and untreated by aqueous extracts of Quina; group 3 sensitized by aloxana ad treated with the aqueous extract of quina. Diabetes was induced by alloxan diabetogenic drugs at a dose of 42 mg/kg of weight. The glycemias was evaluated by glycemic measuring Accu-check®. To verify the healing, was made a longitudinal cut of 1 cm in the back of the mouse. The group 3 was treated with a microemulsion containing Strychnos pseudoquina. Wounds were macroscopically evaluated during pre-determined days after the cut (1st, 3rd, 7th, 9th, 14th). RESULTS: The glycemia levels in the group treated with Strychnos pseudoquina were lower than the group sensitized by alloxan and not treated with Strychnos pseudoquina. There was no difference between the healing of the wounds treated with quina and another groups. CONCLUSIONS: Strychnos pseudoquina presents hypoglycemic effect. Meanwhile the topical use of the microemulsion of Strychnos pseudoquina presents no macroscopically significant effect on the healing of wounds in diabetic rats. |
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Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL)Diabetes MellitusHypoglycemiaWound HealingRatsPURPOSE: Evaluation the hypoglycemic and healing effects of the Strychnos pseudoquina. METHODS: 33 Wistar rats were divided in the following groups, group 1 not sensitized with alloxan and untreated by aqueous extracts; group 2 sensitized with aloxana and untreated by aqueous extracts of Quina; group 3 sensitized by aloxana ad treated with the aqueous extract of quina. Diabetes was induced by alloxan diabetogenic drugs at a dose of 42 mg/kg of weight. The glycemias was evaluated by glycemic measuring Accu-check®. To verify the healing, was made a longitudinal cut of 1 cm in the back of the mouse. The group 3 was treated with a microemulsion containing Strychnos pseudoquina. Wounds were macroscopically evaluated during pre-determined days after the cut (1st, 3rd, 7th, 9th, 14th). RESULTS: The glycemia levels in the group treated with Strychnos pseudoquina were lower than the group sensitized by alloxan and not treated with Strychnos pseudoquina. There was no difference between the healing of the wounds treated with quina and another groups. CONCLUSIONS: Strychnos pseudoquina presents hypoglycemic effect. Meanwhile the topical use of the microemulsion of Strychnos pseudoquina presents no macroscopically significant effect on the healing of wounds in diabetic rats.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600007Acta Cirúrgica Brasileira v.23 n.6 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000600007info:eu-repo/semantics/openAccessHonório-França,Adenilda CristinaMarins,Camila Moreira FerreiraBoldrini,FernandoFrança,Eduardo Luzíaeng2008-11-12T00:00:00Zoai:scielo:S0102-86502008000600007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-11-12T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) |
title |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) |
spellingShingle |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) Honório-França,Adenilda Cristina Diabetes Mellitus Hypoglycemia Wound Healing Rats |
title_short |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) |
title_full |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) |
title_fullStr |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) |
title_full_unstemmed |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) |
title_sort |
Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL) |
author |
Honório-França,Adenilda Cristina |
author_facet |
Honório-França,Adenilda Cristina Marins,Camila Moreira Ferreira Boldrini,Fernando França,Eduardo Luzía |
author_role |
author |
author2 |
Marins,Camila Moreira Ferreira Boldrini,Fernando França,Eduardo Luzía |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Honório-França,Adenilda Cristina Marins,Camila Moreira Ferreira Boldrini,Fernando França,Eduardo Luzía |
dc.subject.por.fl_str_mv |
Diabetes Mellitus Hypoglycemia Wound Healing Rats |
topic |
Diabetes Mellitus Hypoglycemia Wound Healing Rats |
description |
PURPOSE: Evaluation the hypoglycemic and healing effects of the Strychnos pseudoquina. METHODS: 33 Wistar rats were divided in the following groups, group 1 not sensitized with alloxan and untreated by aqueous extracts; group 2 sensitized with aloxana and untreated by aqueous extracts of Quina; group 3 sensitized by aloxana ad treated with the aqueous extract of quina. Diabetes was induced by alloxan diabetogenic drugs at a dose of 42 mg/kg of weight. The glycemias was evaluated by glycemic measuring Accu-check®. To verify the healing, was made a longitudinal cut of 1 cm in the back of the mouse. The group 3 was treated with a microemulsion containing Strychnos pseudoquina. Wounds were macroscopically evaluated during pre-determined days after the cut (1st, 3rd, 7th, 9th, 14th). RESULTS: The glycemia levels in the group treated with Strychnos pseudoquina were lower than the group sensitized by alloxan and not treated with Strychnos pseudoquina. There was no difference between the healing of the wounds treated with quina and another groups. CONCLUSIONS: Strychnos pseudoquina presents hypoglycemic effect. Meanwhile the topical use of the microemulsion of Strychnos pseudoquina presents no macroscopically significant effect on the healing of wounds in diabetic rats. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000600007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502008000600007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.23 n.6 2008 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126439184924672 |