Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy

• Autor(a) principal: Silva,Layla Alves Rodrigues da
• Data de Publicação: 2021
• Outros Autores: Santana,Renato Figueiredo, Achar,Eduardo, Ballester,Gerson, Ortiz,Sandra Regina Mota, Ribeiro Junior,Marcelo Augusto Fontenelle
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502021000200202
• topic: Averrhoa; Seizures; Kidney Diseases; Electroencephalography; Rats

ABSTRACT Purpose To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. Methods Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. Results To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. Conclusions The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.