Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000400003 |
Resumo: | PURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of pulmonary myeloperoxidase (MPO) activity, pulmonary protein extravasation, and serum levels of cytokines and C-reactive protein (CRP) were performed. RESULTS: OLV significantly increased the MPO activity in the collapsed and continuously ventilated lungs (31% and 52% increase, respectively) compared with control (p<0.05). Treatment with simvastatin significantly reduced the MPO activity in the continuously ventilated lung but had no effect on lung edema after OLV. The serum IL-6 and CRP levels were markedly higher in OLV group, but simvastatin treatment failed to affect the production of these inflammatory markers. Serum levels of IL-1β, TNF-α and IL-10 remained below the detection limit in all groups. CONCLUSIONS: In an experimental one-lung ventilation model pre-operative treatment with simvastatin reduces remote neutrophil infiltration in the continuously ventilated lung. Our findings suggest that simvastatin may be of therapeutic value in OLV-induced pulmonary inflammation deserving clinical investigations. |
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Acta Cirúrgica Brasileira (Online) |
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Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in ratsModels, AnimalPulmonary VentilationSimvastatinThoracic SurgeryInflammationRatsPURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of pulmonary myeloperoxidase (MPO) activity, pulmonary protein extravasation, and serum levels of cytokines and C-reactive protein (CRP) were performed. RESULTS: OLV significantly increased the MPO activity in the collapsed and continuously ventilated lungs (31% and 52% increase, respectively) compared with control (p<0.05). Treatment with simvastatin significantly reduced the MPO activity in the continuously ventilated lung but had no effect on lung edema after OLV. The serum IL-6 and CRP levels were markedly higher in OLV group, but simvastatin treatment failed to affect the production of these inflammatory markers. Serum levels of IL-1β, TNF-α and IL-10 remained below the detection limit in all groups. CONCLUSIONS: In an experimental one-lung ventilation model pre-operative treatment with simvastatin reduces remote neutrophil infiltration in the continuously ventilated lung. Our findings suggest that simvastatin may be of therapeutic value in OLV-induced pulmonary inflammation deserving clinical investigations.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000400003Acta Cirúrgica Brasileira v.28 n.4 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013000400003info:eu-repo/semantics/openAccessLeite,Camila FerreiraMarangoni,Fábio AndréCamargo,Enilton AparecidoBraga,Angélica de Fátima de AssunçãoToro,Ivan Felizardo ContreraAntunes,EdsonLanducci,Elen Cristina TiezemMussi,Ricardo Kalafeng2013-04-02T00:00:00Zoai:scielo:S0102-86502013000400003Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-04-02T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats |
title |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats |
spellingShingle |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats Leite,Camila Ferreira Models, Animal Pulmonary Ventilation Simvastatin Thoracic Surgery Inflammation Rats |
title_short |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats |
title_full |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats |
title_fullStr |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats |
title_full_unstemmed |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats |
title_sort |
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats |
author |
Leite,Camila Ferreira |
author_facet |
Leite,Camila Ferreira Marangoni,Fábio André Camargo,Enilton Aparecido Braga,Angélica de Fátima de Assunção Toro,Ivan Felizardo Contrera Antunes,Edson Landucci,Elen Cristina Tiezem Mussi,Ricardo Kalaf |
author_role |
author |
author2 |
Marangoni,Fábio André Camargo,Enilton Aparecido Braga,Angélica de Fátima de Assunção Toro,Ivan Felizardo Contrera Antunes,Edson Landucci,Elen Cristina Tiezem Mussi,Ricardo Kalaf |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Leite,Camila Ferreira Marangoni,Fábio André Camargo,Enilton Aparecido Braga,Angélica de Fátima de Assunção Toro,Ivan Felizardo Contrera Antunes,Edson Landucci,Elen Cristina Tiezem Mussi,Ricardo Kalaf |
dc.subject.por.fl_str_mv |
Models, Animal Pulmonary Ventilation Simvastatin Thoracic Surgery Inflammation Rats |
topic |
Models, Animal Pulmonary Ventilation Simvastatin Thoracic Surgery Inflammation Rats |
description |
PURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of pulmonary myeloperoxidase (MPO) activity, pulmonary protein extravasation, and serum levels of cytokines and C-reactive protein (CRP) were performed. RESULTS: OLV significantly increased the MPO activity in the collapsed and continuously ventilated lungs (31% and 52% increase, respectively) compared with control (p<0.05). Treatment with simvastatin significantly reduced the MPO activity in the continuously ventilated lung but had no effect on lung edema after OLV. The serum IL-6 and CRP levels were markedly higher in OLV group, but simvastatin treatment failed to affect the production of these inflammatory markers. Serum levels of IL-1β, TNF-α and IL-10 remained below the detection limit in all groups. CONCLUSIONS: In an experimental one-lung ventilation model pre-operative treatment with simvastatin reduces remote neutrophil infiltration in the continuously ventilated lung. Our findings suggest that simvastatin may be of therapeutic value in OLV-induced pulmonary inflammation deserving clinical investigations. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000400003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000400003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502013000400003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.28 n.4 2013 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126441730867200 |