New experimental model of exposure to environmental tobacco smoke

• Autor(a) principal: Brito,Marcus Vinicius Henriques
• Data de Publicação: 2013
• Outros Autores: Yasojima,Edson Yuzur, Silveira,Edvaldo Lima, Yamaki,Vitor Nagai, Teixeira,Renan Kleber Costa, Feijó,Daniel Haber, Gonçalves,Thiago Barbosa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001200002
• topic: Lung Diseases; Smoke Inhalation Injury; Rats

PURPOSE: To describe a new model to passive smoking for rodents. METHODS: Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals were exposed to the passive smoking; Euthanasia was performed after 14 days of exposure. The serum level of nicotine and histological analysis were performed. RESULTS: There was a statistical difference on the nicotine serum levels between Experimental and Control group, with level of 286 ±23 nanograma/mL in the EG and undetectable on CG (p<0.01). The histological study suggested the model efficacy producing alveolar destruction and emphysema in the EG compared with the insignificant lesions in the CG's lung. CONCLUSION: The model of exposure to environmental tobacco smoke for rodents induced easily the changes related to secondhand smoke.