New experimental model of exposure to environmental tobacco smoke

• Autor(a) principal: BRITO, Marcus Vinicius Henriques
• Data de Publicação: 2013
• Outros Autores: YASOJIMA, Edson Yuzur, SILVEIRA, Edvaldo Lima, YAMAKI, Vitor Nagai, TEIXEIRA, Renan Kleber Costa, FEIJÓ, Daniel Haber, GONÇALVES, Thiago Barbosa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFPA
• Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/6337; http://dx.doi.org/10.1590/S0102-86502013001200002
• topic: Pneumopatias; Lesão por inalação de fumaça; Rato como animal de laboratório; Lung diseases; Smoke inhalation injury; Rats

PURPOSE: To describe a new model to passive smoking for rodents. METHODS: Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals were exposed to the passive smoking; Euthanasia was performed after 14 days of exposure. The serum level of nicotine and histological analysis were performed. RESULTS: There was a statistical difference on the nicotine serum levels between Experimental and Control group, with level of 286 ±23 nanograma/mL in the EG and undetectable on CG (p<0.01). The histological study suggested the model efficacy producing alveolar destruction and emphysema in the EG compared with the insignificant lesions in the CG's lung. CONCLUSION: The model of exposure to environmental tobacco smoke for rodents induced easily the changes related to secondhand smoke.