An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation

• Autor(a) principal: Migliavacca,Raphaella de Oliveira
• Data de Publicação: 2014
• Outros Autores: Piltcher,Otávio Bejzman, Kliemann,Lúcia Maria, Cerski,Marcelle Reesink, Meyer,Fabíola, Oppermann,Paula de Oliveira, Machado Filho,Geraldo, Kang,Suzie Hyeona, Costa,Sady Selaimen da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500313
• topic: Sinusitis; Disease Models, Animal; Models, Animal; Maxillary Sinusitis; Rabbits

PURPOSE: Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits.METHODS: In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa.RESULTS: Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026).CONCLUSION:It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.