An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/118228 |
Resumo: | PURPOSE: Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits. METHODS: In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa. RESULTS: Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026). CONCLUSION: It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies. |
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Migliavacca, Raphaella de OliveiraPiltcher, Otavio BejzmanKliemann, Lucia MariaCerski, Marcelle ReesinkMeyer, Fabiola SchonsOppermann, Paula de OliveiraMachado Filho, GeraldoKang, Suzie HyeonaCosta, Sady Selaimen da2015-06-26T02:00:04Z20140102-8650http://hdl.handle.net/10183/118228000965332PURPOSE: Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits. METHODS: In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa. RESULTS: Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026). CONCLUSION: It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.application/pdfengActa cirúrgica brasileira. São Paulo. Vol. 29, n. 5 (2014), p. 313-319SinusiteModelos animais de doençasModelos animaisSinusite maxilarCoelhosAn experimental model of chronic rhinosinusitis in rabbits without bacterial inoculationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000965332.pdf000965332.pdfTexto completo (inglês)application/pdf1296281http://www.lume.ufrgs.br/bitstream/10183/118228/1/000965332.pdfa0d8ccf3a664b18d41c3592ab1ac64e5MD51TEXT000965332.pdf.txt000965332.pdf.txtExtracted Texttext/plain26804http://www.lume.ufrgs.br/bitstream/10183/118228/2/000965332.pdf.txt876405645cc0e27f600c6cb378fd13abMD52THUMBNAIL000965332.pdf.jpg000965332.pdf.jpgGenerated Thumbnailimage/jpeg1676http://www.lume.ufrgs.br/bitstream/10183/118228/3/000965332.pdf.jpg2da9971bfb19f2ac9455eb8f325af779MD5310183/1182282018-10-19 10:21:44.986oai:www.lume.ufrgs.br:10183/118228Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2018-10-19T13:21:44Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation |
title |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation |
spellingShingle |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation Migliavacca, Raphaella de Oliveira Sinusite Modelos animais de doenças Modelos animais Sinusite maxilar Coelhos |
title_short |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation |
title_full |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation |
title_fullStr |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation |
title_full_unstemmed |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation |
title_sort |
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation |
author |
Migliavacca, Raphaella de Oliveira |
author_facet |
Migliavacca, Raphaella de Oliveira Piltcher, Otavio Bejzman Kliemann, Lucia Maria Cerski, Marcelle Reesink Meyer, Fabiola Schons Oppermann, Paula de Oliveira Machado Filho, Geraldo Kang, Suzie Hyeona Costa, Sady Selaimen da |
author_role |
author |
author2 |
Piltcher, Otavio Bejzman Kliemann, Lucia Maria Cerski, Marcelle Reesink Meyer, Fabiola Schons Oppermann, Paula de Oliveira Machado Filho, Geraldo Kang, Suzie Hyeona Costa, Sady Selaimen da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Migliavacca, Raphaella de Oliveira Piltcher, Otavio Bejzman Kliemann, Lucia Maria Cerski, Marcelle Reesink Meyer, Fabiola Schons Oppermann, Paula de Oliveira Machado Filho, Geraldo Kang, Suzie Hyeona Costa, Sady Selaimen da |
dc.subject.por.fl_str_mv |
Sinusite Modelos animais de doenças Modelos animais Sinusite maxilar Coelhos |
topic |
Sinusite Modelos animais de doenças Modelos animais Sinusite maxilar Coelhos |
description |
PURPOSE: Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits. METHODS: In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa. RESULTS: Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026). CONCLUSION: It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-06-26T02:00:04Z |
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article |
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0102-8650 |
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000965332 |
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http://hdl.handle.net/10183/118228 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Acta cirúrgica brasileira. São Paulo. Vol. 29, n. 5 (2014), p. 313-319 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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