An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation

• Autor(a) principal: Migliavacca, Raphaella de Oliveira
• Data de Publicação: 2014
• Outros Autores: Piltcher, Otavio Bejzman, Kliemann, Lucia Maria, Cerski, Marcelle Reesink, Meyer, Fabiola Schons, Oppermann, Paula de Oliveira, Machado Filho, Geraldo, Kang, Suzie Hyeona, Costa, Sady Selaimen da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/118228
• topic: Sinusite; Modelos animais de doenças; Modelos animais; Sinusite maxilar; Coelhos

PURPOSE: Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits. METHODS: In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa. RESULTS: Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026). CONCLUSION: It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.