Is the colon mucosa affected by ten days of gastric restriction in an animal model?
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000600209 |
Resumo: | Abstract Purpose To identify whether the colon mucosa is affected by ten days of gastric restriction in an animal model. Methods An experimental model of gastric restriction was devised using rats. The animals were submitted to surgical gastrostomy, and a cylindrical loofah was inserted into the stomach. We studied 30 adult male Wistar rats divided into three groups: the stomach restriction group (R10); the sham group (S10), which underwent the same procedure except for the loofah insertion; and the control group (C10). The expression of neutral and acid mucins was evaluated using histochemical techniques. Goblet cells and protein content were compared between groups using generalized estimation equations (GEEs). Bonferroni’s multiple comparison was applied to identify differences between the groups. All tests considered a 5% significance level. Results There was an increased expression of neutral mucins, acid mucins and goblet cells in the R10 group. Collagen was also enhanced in the R10 group. Conclusion The colon mucosa is affected by ten days of gastric restriction in an animal model, increasing neutral mucins, acid mucins and collagen content with trophic maintenance. |
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Is the colon mucosa affected by ten days of gastric restriction in an animal model?Models, animalColonMucinsRatsAbstract Purpose To identify whether the colon mucosa is affected by ten days of gastric restriction in an animal model. Methods An experimental model of gastric restriction was devised using rats. The animals were submitted to surgical gastrostomy, and a cylindrical loofah was inserted into the stomach. We studied 30 adult male Wistar rats divided into three groups: the stomach restriction group (R10); the sham group (S10), which underwent the same procedure except for the loofah insertion; and the control group (C10). The expression of neutral and acid mucins was evaluated using histochemical techniques. Goblet cells and protein content were compared between groups using generalized estimation equations (GEEs). Bonferroni’s multiple comparison was applied to identify differences between the groups. All tests considered a 5% significance level. Results There was an increased expression of neutral mucins, acid mucins and goblet cells in the R10 group. Collagen was also enhanced in the R10 group. Conclusion The colon mucosa is affected by ten days of gastric restriction in an animal model, increasing neutral mucins, acid mucins and collagen content with trophic maintenance.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000600209Acta Cirúrgica Brasileira v.34 n.6 2019reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020190060000010info:eu-repo/semantics/openAccessAkamatsu,Flávia EmiFontes,Luiz GustavoItezerote,Ana MariaSaleh,SamirTeodoro,Walcy Paganelli RosoliaArtifon,EversonHojaij,FlávioAndrade,MauroPereira,José AiresMartinez,Carlos Augusto RealJacomo,Alfredo Luizeng2019-08-16T00:00:00Zoai:scielo:S0102-86502019000600209Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2019-08-16T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? |
title |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? |
spellingShingle |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? Akamatsu,Flávia Emi Models, animal Colon Mucins Rats |
title_short |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? |
title_full |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? |
title_fullStr |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? |
title_full_unstemmed |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? |
title_sort |
Is the colon mucosa affected by ten days of gastric restriction in an animal model? |
author |
Akamatsu,Flávia Emi |
author_facet |
Akamatsu,Flávia Emi Fontes,Luiz Gustavo Itezerote,Ana Maria Saleh,Samir Teodoro,Walcy Paganelli Rosolia Artifon,Everson Hojaij,Flávio Andrade,Mauro Pereira,José Aires Martinez,Carlos Augusto Real Jacomo,Alfredo Luiz |
author_role |
author |
author2 |
Fontes,Luiz Gustavo Itezerote,Ana Maria Saleh,Samir Teodoro,Walcy Paganelli Rosolia Artifon,Everson Hojaij,Flávio Andrade,Mauro Pereira,José Aires Martinez,Carlos Augusto Real Jacomo,Alfredo Luiz |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Akamatsu,Flávia Emi Fontes,Luiz Gustavo Itezerote,Ana Maria Saleh,Samir Teodoro,Walcy Paganelli Rosolia Artifon,Everson Hojaij,Flávio Andrade,Mauro Pereira,José Aires Martinez,Carlos Augusto Real Jacomo,Alfredo Luiz |
dc.subject.por.fl_str_mv |
Models, animal Colon Mucins Rats |
topic |
Models, animal Colon Mucins Rats |
description |
Abstract Purpose To identify whether the colon mucosa is affected by ten days of gastric restriction in an animal model. Methods An experimental model of gastric restriction was devised using rats. The animals were submitted to surgical gastrostomy, and a cylindrical loofah was inserted into the stomach. We studied 30 adult male Wistar rats divided into three groups: the stomach restriction group (R10); the sham group (S10), which underwent the same procedure except for the loofah insertion; and the control group (C10). The expression of neutral and acid mucins was evaluated using histochemical techniques. Goblet cells and protein content were compared between groups using generalized estimation equations (GEEs). Bonferroni’s multiple comparison was applied to identify differences between the groups. All tests considered a 5% significance level. Results There was an increased expression of neutral mucins, acid mucins and goblet cells in the R10 group. Collagen was also enhanced in the R10 group. Conclusion The colon mucosa is affected by ten days of gastric restriction in an animal model, increasing neutral mucins, acid mucins and collagen content with trophic maintenance. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000600209 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000600209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0102-865020190060000010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.34 n.6 2019 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126445396688896 |