Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats

Detalhes bibliográficos
Autor(a) principal: Gumieiro,Emne Hammoud
Data de Publicação: 2010
Outros Autores: Abrahão,Márcio, Jahn,Ricardo Schmitutz, Segretto,Helena, Alves,Maria Tereza de Seixas, Nannmark,Ulf, Granström,Gösta, Dib,Luciano Lauria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300007
Resumo: PURPOSE: To evaluate the influence of PRP addition on bone repair of circular defects created in irradiated tibiae of rats by histometric analysis. METHODS: Sixty male Wistar rats had the right tibiae irradiated with 30 Gy. After 30 days monocortical defects were created and platelet-rich plasma was applied in 30 rats. In the control group defects were created but not filled. The animals were desanguinated after 4, 7, 14, 21, 56 and 84 days and the tibiae removed for histological processing. RESULTS: There was a tendency in the PRP group to increased bone neoformation from 14-days to 84-days; in the control group increased bone neoformation was not seen after 21 days or later. CONCLUSION: The addition of platelet-rich plasma had a beneficial effect in the initial cellular regeneration period and enhanced bone formation in later periods when compared to control.
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spelling Platelet-rich plasma in bone repair of irradiated tibiae of Wistar ratsPlatelet-Rich PlasmaRadiation Injuries, ExperimentalBone RegenerationPURPOSE: To evaluate the influence of PRP addition on bone repair of circular defects created in irradiated tibiae of rats by histometric analysis. METHODS: Sixty male Wistar rats had the right tibiae irradiated with 30 Gy. After 30 days monocortical defects were created and platelet-rich plasma was applied in 30 rats. In the control group defects were created but not filled. The animals were desanguinated after 4, 7, 14, 21, 56 and 84 days and the tibiae removed for histological processing. RESULTS: There was a tendency in the PRP group to increased bone neoformation from 14-days to 84-days; in the control group increased bone neoformation was not seen after 21 days or later. CONCLUSION: The addition of platelet-rich plasma had a beneficial effect in the initial cellular regeneration period and enhanced bone formation in later periods when compared to control.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300007Acta Cirúrgica Brasileira v.25 n.3 2010reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502010000300007info:eu-repo/semantics/openAccessGumieiro,Emne HammoudAbrahão,MárcioJahn,Ricardo SchmitutzSegretto,HelenaAlves,Maria Tereza de SeixasNannmark,UlfGranström,GöstaDib,Luciano Lauriaeng2010-05-21T00:00:00Zoai:scielo:S0102-86502010000300007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2010-05-21T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
title Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
spellingShingle Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
Gumieiro,Emne Hammoud
Platelet-Rich Plasma
Radiation Injuries, Experimental
Bone Regeneration
title_short Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
title_full Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
title_fullStr Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
title_full_unstemmed Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
title_sort Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
author Gumieiro,Emne Hammoud
author_facet Gumieiro,Emne Hammoud
Abrahão,Márcio
Jahn,Ricardo Schmitutz
Segretto,Helena
Alves,Maria Tereza de Seixas
Nannmark,Ulf
Granström,Gösta
Dib,Luciano Lauria
author_role author
author2 Abrahão,Márcio
Jahn,Ricardo Schmitutz
Segretto,Helena
Alves,Maria Tereza de Seixas
Nannmark,Ulf
Granström,Gösta
Dib,Luciano Lauria
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gumieiro,Emne Hammoud
Abrahão,Márcio
Jahn,Ricardo Schmitutz
Segretto,Helena
Alves,Maria Tereza de Seixas
Nannmark,Ulf
Granström,Gösta
Dib,Luciano Lauria
dc.subject.por.fl_str_mv Platelet-Rich Plasma
Radiation Injuries, Experimental
Bone Regeneration
topic Platelet-Rich Plasma
Radiation Injuries, Experimental
Bone Regeneration
description PURPOSE: To evaluate the influence of PRP addition on bone repair of circular defects created in irradiated tibiae of rats by histometric analysis. METHODS: Sixty male Wistar rats had the right tibiae irradiated with 30 Gy. After 30 days monocortical defects were created and platelet-rich plasma was applied in 30 rats. In the control group defects were created but not filled. The animals were desanguinated after 4, 7, 14, 21, 56 and 84 days and the tibiae removed for histological processing. RESULTS: There was a tendency in the PRP group to increased bone neoformation from 14-days to 84-days; in the control group increased bone neoformation was not seen after 21 days or later. CONCLUSION: The addition of platelet-rich plasma had a beneficial effect in the initial cellular regeneration period and enhanced bone formation in later periods when compared to control.
publishDate 2010
dc.date.none.fl_str_mv 2010-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502010000300007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.25 n.3 2010
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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