Does metoclopramide impair anastomotic healing of the left colon of rats?

Detalhes bibliográficos
Autor(a) principal: Silva,Silvana Marques e
Data de Publicação: 2011
Outros Autores: Ferreira,Vânia Maria Moraes, Feres,Omar, Oliveira,Paulo Gonçalves de, Sousa,João Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400009
Resumo: PURPOSE: To evaluate the effects of metoclopramide on the formation of adhesion and the healing of left colonic anastomoses in rats. METHODS: Forty rats underwent sectioning of the left colon and end-to-end anastomosis and were divided into two groups of 20 animals for the administration of metoclopramide (experimental group - E) or saline solution (control group - C). Each group was divided into subgroups of 10 animals each to be killed on the third (E3 and C3) or seventh postoperative day (E7 and C7). Adhesion was assessed, and a colonic segment containing the anastomosis was removed for analysis of breaking strength and hydroxyproline concentration. RESULTS: There were no deaths or dehiscence on the 3rd postoperative day. There was one death and one blocked anastomotic dehiscence in the E7 group. No significant differences between groups were found in the analysis of clinical outcome, intra-cavity adhesion, adhesion to the anastomosis or breaking strength on the 3rd and 7th postoperative day. Hydroxyproline concentration was higher in the control group on the 3rd (p=0.006) but not on the 7th postoperative day (p=0.241). CONCLUSION: Metoclopramide did not have harmful effects on the healing of intestinal anastomoses in rats.
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spelling Does metoclopramide impair anastomotic healing of the left colon of rats?Anastomosis, SurgicalColonMetoclopramideGastrointestinal MotilityTissue AdhesionsRatsPURPOSE: To evaluate the effects of metoclopramide on the formation of adhesion and the healing of left colonic anastomoses in rats. METHODS: Forty rats underwent sectioning of the left colon and end-to-end anastomosis and were divided into two groups of 20 animals for the administration of metoclopramide (experimental group - E) or saline solution (control group - C). Each group was divided into subgroups of 10 animals each to be killed on the third (E3 and C3) or seventh postoperative day (E7 and C7). Adhesion was assessed, and a colonic segment containing the anastomosis was removed for analysis of breaking strength and hydroxyproline concentration. RESULTS: There were no deaths or dehiscence on the 3rd postoperative day. There was one death and one blocked anastomotic dehiscence in the E7 group. No significant differences between groups were found in the analysis of clinical outcome, intra-cavity adhesion, adhesion to the anastomosis or breaking strength on the 3rd and 7th postoperative day. Hydroxyproline concentration was higher in the control group on the 3rd (p=0.006) but not on the 7th postoperative day (p=0.241). CONCLUSION: Metoclopramide did not have harmful effects on the healing of intestinal anastomoses in rats.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400009Acta Cirúrgica Brasileira v.26 n.4 2011reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502011000400009info:eu-repo/semantics/openAccessSilva,Silvana Marques eFerreira,Vânia Maria MoraesFeres,OmarOliveira,Paulo Gonçalves deSousa,João Batista deeng2011-07-25T00:00:00Zoai:scielo:S0102-86502011000400009Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2011-07-25T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Does metoclopramide impair anastomotic healing of the left colon of rats?
title Does metoclopramide impair anastomotic healing of the left colon of rats?
spellingShingle Does metoclopramide impair anastomotic healing of the left colon of rats?
Silva,Silvana Marques e
Anastomosis, Surgical
Colon
Metoclopramide
Gastrointestinal Motility
Tissue Adhesions
Rats
title_short Does metoclopramide impair anastomotic healing of the left colon of rats?
title_full Does metoclopramide impair anastomotic healing of the left colon of rats?
title_fullStr Does metoclopramide impair anastomotic healing of the left colon of rats?
title_full_unstemmed Does metoclopramide impair anastomotic healing of the left colon of rats?
title_sort Does metoclopramide impair anastomotic healing of the left colon of rats?
author Silva,Silvana Marques e
author_facet Silva,Silvana Marques e
Ferreira,Vânia Maria Moraes
Feres,Omar
Oliveira,Paulo Gonçalves de
Sousa,João Batista de
author_role author
author2 Ferreira,Vânia Maria Moraes
Feres,Omar
Oliveira,Paulo Gonçalves de
Sousa,João Batista de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva,Silvana Marques e
Ferreira,Vânia Maria Moraes
Feres,Omar
Oliveira,Paulo Gonçalves de
Sousa,João Batista de
dc.subject.por.fl_str_mv Anastomosis, Surgical
Colon
Metoclopramide
Gastrointestinal Motility
Tissue Adhesions
Rats
topic Anastomosis, Surgical
Colon
Metoclopramide
Gastrointestinal Motility
Tissue Adhesions
Rats
description PURPOSE: To evaluate the effects of metoclopramide on the formation of adhesion and the healing of left colonic anastomoses in rats. METHODS: Forty rats underwent sectioning of the left colon and end-to-end anastomosis and were divided into two groups of 20 animals for the administration of metoclopramide (experimental group - E) or saline solution (control group - C). Each group was divided into subgroups of 10 animals each to be killed on the third (E3 and C3) or seventh postoperative day (E7 and C7). Adhesion was assessed, and a colonic segment containing the anastomosis was removed for analysis of breaking strength and hydroxyproline concentration. RESULTS: There were no deaths or dehiscence on the 3rd postoperative day. There was one death and one blocked anastomotic dehiscence in the E7 group. No significant differences between groups were found in the analysis of clinical outcome, intra-cavity adhesion, adhesion to the anastomosis or breaking strength on the 3rd and 7th postoperative day. Hydroxyproline concentration was higher in the control group on the 3rd (p=0.006) but not on the 7th postoperative day (p=0.241). CONCLUSION: Metoclopramide did not have harmful effects on the healing of intestinal anastomoses in rats.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502011000400009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.26 n.4 2011
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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