Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000700008 |
Resumo: | PURPOSE: To investigate the effect of lovastatin on renal ischemia followed by reperfusion. METHODS: Thirty one Wistar rats submitted to left renal ischemia for 60 minutes followed by contralateral nephrectomy were divided into two groups: A (n =17, control, no treatment), and B (n=14, lovastatin 15 mg/kg/day p.o. ten days before ischemia). The animals were sacrificed at the end of ischemia, after 24 hours and at seven days after reperfusion. Survival, serum urea and creatinine levels and renal mitochondrial function were evaluated. RESULTS: Mortality was 29.4% in group A and 0.7% in group B. Urea and creatinine levels were increased in both groups, but the values were significantly lower in group B. Mitochondrial function showed decoupling in 83.4% of group A, as opposed to 38.4/% of group B. CONCLUSIONS: The result shows a protective action of renal function by lovastatin administered before ischemia/reperfusion. Since most of the mitochondrial fraction presented membranes with the ability to maintain ATP production in group B, stabilization of the mitochondrial membrane should be considered as part of the protective action of lovastatin on renal function in ischemia/reperfusion. |
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Acta Cirúrgica Brasileira (Online) |
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Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in ratsLovastatinMitochondriaReperfusion InjuryIschemiaRatsPURPOSE: To investigate the effect of lovastatin on renal ischemia followed by reperfusion. METHODS: Thirty one Wistar rats submitted to left renal ischemia for 60 minutes followed by contralateral nephrectomy were divided into two groups: A (n =17, control, no treatment), and B (n=14, lovastatin 15 mg/kg/day p.o. ten days before ischemia). The animals were sacrificed at the end of ischemia, after 24 hours and at seven days after reperfusion. Survival, serum urea and creatinine levels and renal mitochondrial function were evaluated. RESULTS: Mortality was 29.4% in group A and 0.7% in group B. Urea and creatinine levels were increased in both groups, but the values were significantly lower in group B. Mitochondrial function showed decoupling in 83.4% of group A, as opposed to 38.4/% of group B. CONCLUSIONS: The result shows a protective action of renal function by lovastatin administered before ischemia/reperfusion. Since most of the mitochondrial fraction presented membranes with the ability to maintain ATP production in group B, stabilization of the mitochondrial membrane should be considered as part of the protective action of lovastatin on renal function in ischemia/reperfusion.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000700008Acta Cirúrgica Brasileira v.27 n.7 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012000700008info:eu-repo/semantics/openAccessTucci Junior,SilvioMolina,Carlos Augusto FernandesCassini,Marcelo FerreiraLeal,Daniel MendesSchineider,Cássio Antonio BoteneMartins,Antonio Carlos Pereiraeng2012-06-27T00:00:00Zoai:scielo:S0102-86502012000700008Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-06-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats |
title |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats |
spellingShingle |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats Tucci Junior,Silvio Lovastatin Mitochondria Reperfusion Injury Ischemia Rats |
title_short |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats |
title_full |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats |
title_fullStr |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats |
title_full_unstemmed |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats |
title_sort |
Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats |
author |
Tucci Junior,Silvio |
author_facet |
Tucci Junior,Silvio Molina,Carlos Augusto Fernandes Cassini,Marcelo Ferreira Leal,Daniel Mendes Schineider,Cássio Antonio Botene Martins,Antonio Carlos Pereira |
author_role |
author |
author2 |
Molina,Carlos Augusto Fernandes Cassini,Marcelo Ferreira Leal,Daniel Mendes Schineider,Cássio Antonio Botene Martins,Antonio Carlos Pereira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Tucci Junior,Silvio Molina,Carlos Augusto Fernandes Cassini,Marcelo Ferreira Leal,Daniel Mendes Schineider,Cássio Antonio Botene Martins,Antonio Carlos Pereira |
dc.subject.por.fl_str_mv |
Lovastatin Mitochondria Reperfusion Injury Ischemia Rats |
topic |
Lovastatin Mitochondria Reperfusion Injury Ischemia Rats |
description |
PURPOSE: To investigate the effect of lovastatin on renal ischemia followed by reperfusion. METHODS: Thirty one Wistar rats submitted to left renal ischemia for 60 minutes followed by contralateral nephrectomy were divided into two groups: A (n =17, control, no treatment), and B (n=14, lovastatin 15 mg/kg/day p.o. ten days before ischemia). The animals were sacrificed at the end of ischemia, after 24 hours and at seven days after reperfusion. Survival, serum urea and creatinine levels and renal mitochondrial function were evaluated. RESULTS: Mortality was 29.4% in group A and 0.7% in group B. Urea and creatinine levels were increased in both groups, but the values were significantly lower in group B. Mitochondrial function showed decoupling in 83.4% of group A, as opposed to 38.4/% of group B. CONCLUSIONS: The result shows a protective action of renal function by lovastatin administered before ischemia/reperfusion. Since most of the mitochondrial fraction presented membranes with the ability to maintain ATP production in group B, stabilization of the mitochondrial membrane should be considered as part of the protective action of lovastatin on renal function in ischemia/reperfusion. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000700008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000700008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502012000700008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.27 n.7 2012 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126441273688064 |