Amniotic membrane as a biological dressing in infected wound healing in rabbits

Detalhes bibliográficos
Autor(a) principal: Duarte,Ian Göedert Leite
Data de Publicação: 2014
Outros Autores: Duval-Araujo,Ivana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500334
Resumo: PURPOSE:To investigate amniotic membrane as a biological dressing in infected wound healing in rabbits.METHODS: The use of preserved amniotic membranes (AMs) was examined using 15 rabbits with experimentally induced wound infections on their backs. Healing was histologically evaluated during different phases including inflammation, granulation, epithelialization, and fibroplasia. The animals were distributed into three groups for histological study at seven, 14, 21, and 28 days post-wound induction. Group A did not receive treatment: the wound was left exposed and dry; Group B received a daily exposure treatment with collagenase; and Group C received one AM, which also remained exposed.RESULTS: A marked reduction of the inflammatory phase was observed in Group C at 21 days, and the granulation phase of this healing increased at 14 days. Epithelialization was similar among the three groups, and fibroplasia was more pronounced in Group C at 14 days. Furthermore, gradual collagen organization also began for the animals in Group B at 14 days.CONCLUSION:The amniotic membrane did not significantly alter the inflammation, epithelialization, or fibroplasia phases but did increase angiogenesis up to Day 14 compared with the dry dressing and collagenase treatments.
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spelling Amniotic membrane as a biological dressing in infected wound healing in rabbitsBiological DressingsGranulation TissueWound HealingRabbitsPURPOSE:To investigate amniotic membrane as a biological dressing in infected wound healing in rabbits.METHODS: The use of preserved amniotic membranes (AMs) was examined using 15 rabbits with experimentally induced wound infections on their backs. Healing was histologically evaluated during different phases including inflammation, granulation, epithelialization, and fibroplasia. The animals were distributed into three groups for histological study at seven, 14, 21, and 28 days post-wound induction. Group A did not receive treatment: the wound was left exposed and dry; Group B received a daily exposure treatment with collagenase; and Group C received one AM, which also remained exposed.RESULTS: A marked reduction of the inflammatory phase was observed in Group C at 21 days, and the granulation phase of this healing increased at 14 days. Epithelialization was similar among the three groups, and fibroplasia was more pronounced in Group C at 14 days. Furthermore, gradual collagen organization also began for the animals in Group B at 14 days.CONCLUSION:The amniotic membrane did not significantly alter the inflammation, epithelialization, or fibroplasia phases but did increase angiogenesis up to Day 14 compared with the dry dressing and collagenase treatments.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500334Acta Cirúrgica Brasileira v.29 n.5 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502014000500008info:eu-repo/semantics/openAccessDuarte,Ian Göedert LeiteDuval-Araujo,Ivanaeng2015-10-08T00:00:00Zoai:scielo:S0102-86502014000500334Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Amniotic membrane as a biological dressing in infected wound healing in rabbits
title Amniotic membrane as a biological dressing in infected wound healing in rabbits
spellingShingle Amniotic membrane as a biological dressing in infected wound healing in rabbits
Duarte,Ian Göedert Leite
Biological Dressings
Granulation Tissue
Wound Healing
Rabbits
title_short Amniotic membrane as a biological dressing in infected wound healing in rabbits
title_full Amniotic membrane as a biological dressing in infected wound healing in rabbits
title_fullStr Amniotic membrane as a biological dressing in infected wound healing in rabbits
title_full_unstemmed Amniotic membrane as a biological dressing in infected wound healing in rabbits
title_sort Amniotic membrane as a biological dressing in infected wound healing in rabbits
author Duarte,Ian Göedert Leite
author_facet Duarte,Ian Göedert Leite
Duval-Araujo,Ivana
author_role author
author2 Duval-Araujo,Ivana
author2_role author
dc.contributor.author.fl_str_mv Duarte,Ian Göedert Leite
Duval-Araujo,Ivana
dc.subject.por.fl_str_mv Biological Dressings
Granulation Tissue
Wound Healing
Rabbits
topic Biological Dressings
Granulation Tissue
Wound Healing
Rabbits
description PURPOSE:To investigate amniotic membrane as a biological dressing in infected wound healing in rabbits.METHODS: The use of preserved amniotic membranes (AMs) was examined using 15 rabbits with experimentally induced wound infections on their backs. Healing was histologically evaluated during different phases including inflammation, granulation, epithelialization, and fibroplasia. The animals were distributed into three groups for histological study at seven, 14, 21, and 28 days post-wound induction. Group A did not receive treatment: the wound was left exposed and dry; Group B received a daily exposure treatment with collagenase; and Group C received one AM, which also remained exposed.RESULTS: A marked reduction of the inflammatory phase was observed in Group C at 21 days, and the granulation phase of this healing increased at 14 days. Epithelialization was similar among the three groups, and fibroplasia was more pronounced in Group C at 14 days. Furthermore, gradual collagen organization also began for the animals in Group B at 14 days.CONCLUSION:The amniotic membrane did not significantly alter the inflammation, epithelialization, or fibroplasia phases but did increase angiogenesis up to Day 14 compared with the dry dressing and collagenase treatments.
publishDate 2014
dc.date.none.fl_str_mv 2014-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500334
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500334
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502014000500008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.29 n.5 2014
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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