Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016 |
Resumo: | The aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group were euthanized 3, 7, 14 or 21 days after surgical procedures and the wounded areas were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin-Eosin-HEand Sirius red) and immunohistochemical techniques. Topical application of atranorin reduced wound areas, induced earlier granulation tissue formation, increased cell proliferation, improved collagenization and modulated the myofibroblasts differentiation when compared to control animals. It is suggested that atranorin modulates the wound healing process. These data suggest that this formulation based on atranorin extracted from Cladina kalbii AHTI may be a new biotechnological product for wound healing clinical applications. |
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Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodentsatranorinbiomedicinal technologygranulation tissuenatural productswound healingThe aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group were euthanized 3, 7, 14 or 21 days after surgical procedures and the wounded areas were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin-Eosin-HEand Sirius red) and immunohistochemical techniques. Topical application of atranorin reduced wound areas, induced earlier granulation tissue formation, increased cell proliferation, improved collagenization and modulated the myofibroblasts differentiation when compared to control animals. It is suggested that atranorin modulates the wound healing process. These data suggest that this formulation based on atranorin extracted from Cladina kalbii AHTI may be a new biotechnological product for wound healing clinical applications.Sociedade Brasileira de Farmacognosia2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016Revista Brasileira de Farmacognosia v.23 n.2 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013005000010info:eu-repo/semantics/openAccessBarreto,Rosana S. S.Albuquerque-Júnior,Ricardo L. C.Pereira-Filho,Rose NelyQuintans,Jullyana S. S.Barreto,André S.DeSantana,Josimari M.Santana-Filho,Valter J.Santos,Marcio R. V.Bonjardim,Leonardo R.Araújo,Adriano A. S.Quintans-Júnior,Lucindo J.eng2013-03-27T00:00:00Zoai:scielo:S0102-695X2013000200016Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2013-03-27T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents |
title |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents |
spellingShingle |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents Barreto,Rosana S. S. atranorin biomedicinal technology granulation tissue natural products wound healing |
title_short |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents |
title_full |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents |
title_fullStr |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents |
title_full_unstemmed |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents |
title_sort |
Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents |
author |
Barreto,Rosana S. S. |
author_facet |
Barreto,Rosana S. S. Albuquerque-Júnior,Ricardo L. C. Pereira-Filho,Rose Nely Quintans,Jullyana S. S. Barreto,André S. DeSantana,Josimari M. Santana-Filho,Valter J. Santos,Marcio R. V. Bonjardim,Leonardo R. Araújo,Adriano A. S. Quintans-Júnior,Lucindo J. |
author_role |
author |
author2 |
Albuquerque-Júnior,Ricardo L. C. Pereira-Filho,Rose Nely Quintans,Jullyana S. S. Barreto,André S. DeSantana,Josimari M. Santana-Filho,Valter J. Santos,Marcio R. V. Bonjardim,Leonardo R. Araújo,Adriano A. S. Quintans-Júnior,Lucindo J. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Barreto,Rosana S. S. Albuquerque-Júnior,Ricardo L. C. Pereira-Filho,Rose Nely Quintans,Jullyana S. S. Barreto,André S. DeSantana,Josimari M. Santana-Filho,Valter J. Santos,Marcio R. V. Bonjardim,Leonardo R. Araújo,Adriano A. S. Quintans-Júnior,Lucindo J. |
dc.subject.por.fl_str_mv |
atranorin biomedicinal technology granulation tissue natural products wound healing |
topic |
atranorin biomedicinal technology granulation tissue natural products wound healing |
description |
The aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group were euthanized 3, 7, 14 or 21 days after surgical procedures and the wounded areas were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin-Eosin-HEand Sirius red) and immunohistochemical techniques. Topical application of atranorin reduced wound areas, induced earlier granulation tissue formation, increased cell proliferation, improved collagenization and modulated the myofibroblasts differentiation when compared to control animals. It is suggested that atranorin modulates the wound healing process. These data suggest that this formulation based on atranorin extracted from Cladina kalbii AHTI may be a new biotechnological product for wound healing clinical applications. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2013005000010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.23 n.2 2013 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122468713103360 |