Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents

Detalhes bibliográficos
Autor(a) principal: Barreto,Rosana S. S.
Data de Publicação: 2013
Outros Autores: Albuquerque-Júnior,Ricardo L. C., Pereira-Filho,Rose Nely, Quintans,Jullyana S. S., Barreto,André S., DeSantana,Josimari M., Santana-Filho,Valter J., Santos,Marcio R. V., Bonjardim,Leonardo R., Araújo,Adriano A. S., Quintans-Júnior,Lucindo J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016
Resumo: The aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group were euthanized 3, 7, 14 or 21 days after surgical procedures and the wounded areas were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin-Eosin-HEand Sirius red) and immunohistochemical techniques. Topical application of atranorin reduced wound areas, induced earlier granulation tissue formation, increased cell proliferation, improved collagenization and modulated the myofibroblasts differentiation when compared to control animals. It is suggested that atranorin modulates the wound healing process. These data suggest that this formulation based on atranorin extracted from Cladina kalbii AHTI may be a new biotechnological product for wound healing clinical applications.
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spelling Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodentsatranorinbiomedicinal technologygranulation tissuenatural productswound healingThe aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group were euthanized 3, 7, 14 or 21 days after surgical procedures and the wounded areas were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin-Eosin-HEand Sirius red) and immunohistochemical techniques. Topical application of atranorin reduced wound areas, induced earlier granulation tissue formation, increased cell proliferation, improved collagenization and modulated the myofibroblasts differentiation when compared to control animals. It is suggested that atranorin modulates the wound healing process. These data suggest that this formulation based on atranorin extracted from Cladina kalbii AHTI may be a new biotechnological product for wound healing clinical applications.Sociedade Brasileira de Farmacognosia2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016Revista Brasileira de Farmacognosia v.23 n.2 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013005000010info:eu-repo/semantics/openAccessBarreto,Rosana S. S.Albuquerque-Júnior,Ricardo L. C.Pereira-Filho,Rose NelyQuintans,Jullyana S. S.Barreto,André S.DeSantana,Josimari M.Santana-Filho,Valter J.Santos,Marcio R. V.Bonjardim,Leonardo R.Araújo,Adriano A. S.Quintans-Júnior,Lucindo J.eng2013-03-27T00:00:00Zoai:scielo:S0102-695X2013000200016Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2013-03-27T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
title Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
spellingShingle Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
Barreto,Rosana S. S.
atranorin
biomedicinal technology
granulation tissue
natural products
wound healing
title_short Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
title_full Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
title_fullStr Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
title_full_unstemmed Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
title_sort Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents
author Barreto,Rosana S. S.
author_facet Barreto,Rosana S. S.
Albuquerque-Júnior,Ricardo L. C.
Pereira-Filho,Rose Nely
Quintans,Jullyana S. S.
Barreto,André S.
DeSantana,Josimari M.
Santana-Filho,Valter J.
Santos,Marcio R. V.
Bonjardim,Leonardo R.
Araújo,Adriano A. S.
Quintans-Júnior,Lucindo J.
author_role author
author2 Albuquerque-Júnior,Ricardo L. C.
Pereira-Filho,Rose Nely
Quintans,Jullyana S. S.
Barreto,André S.
DeSantana,Josimari M.
Santana-Filho,Valter J.
Santos,Marcio R. V.
Bonjardim,Leonardo R.
Araújo,Adriano A. S.
Quintans-Júnior,Lucindo J.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barreto,Rosana S. S.
Albuquerque-Júnior,Ricardo L. C.
Pereira-Filho,Rose Nely
Quintans,Jullyana S. S.
Barreto,André S.
DeSantana,Josimari M.
Santana-Filho,Valter J.
Santos,Marcio R. V.
Bonjardim,Leonardo R.
Araújo,Adriano A. S.
Quintans-Júnior,Lucindo J.
dc.subject.por.fl_str_mv atranorin
biomedicinal technology
granulation tissue
natural products
wound healing
topic atranorin
biomedicinal technology
granulation tissue
natural products
wound healing
description The aim of this study was to investigate the wound healing activity of atranorin cream (Patent requested) on excision wounds. Seventy-two male rats were anesthetized and an excisional wound was performed. Then the rats were randomly assigned into three groups: untreated control group; atranorin 1 (group treated with 1% AT ointment); and atranorin 5 (group treated with 5% AT ointment). Six animals of each group were euthanized 3, 7, 14 or 21 days after surgical procedures and the wounded areas were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin-Eosin-HEand Sirius red) and immunohistochemical techniques. Topical application of atranorin reduced wound areas, induced earlier granulation tissue formation, increased cell proliferation, improved collagenization and modulated the myofibroblasts differentiation when compared to control animals. It is suggested that atranorin modulates the wound healing process. These data suggest that this formulation based on atranorin extracted from Cladina kalbii AHTI may be a new biotechnological product for wound healing clinical applications.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2013005000010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.23 n.2 2013
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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