The acute effects of preoperative ozone theraphy on surgical wound healing

Detalhes bibliográficos
Autor(a) principal: Sahin,Hasan
Data de Publicação: 2016
Outros Autores: Simsek,Tuncer, Turkon,Hakan, Kalkan,Yıldıray, Ozkul,Faruk, Ozkan,M Turgut Alper, Erbas,Mesut, Altinisik,Ugur, Demiraran,Yavuz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000700472
Resumo: ABSTRACT PURPOSE: To investigate the effects of preoperative rectal ozone insufflation on surgical wound healing over the proinflammatory cytokines and histopathological changes. METHODS: Twenty one rabbits were divided into 3 groups. Sham, surgical wound, and ozone applied (6 sessions, every other day 70 µg/mL in 12 mL O2-O3 mixture rectally) surgical wound groups were created. TNF-alpha and IL-6 levels from all rabbits were studied at the basal, 24th hour, and 72nd hour. The histopathological examination was done by removing the surgical scar tissue at the end of 72nd hour. RESULTS: TNF-alfa and IL-6 levels were significantly lower compared to the control group, in the rabbits treated with ozone. The increase in angiogenesis, the decrease in the number of inflammatory cells, epidermal and dermal regeneration, better collagen deposition, and increased keratinisation in stratum corneum were observed in the histopathological examination. It was determined that the wound healing noticeably accelerated in the ozone group. CONCLUSION: Preoperative rectal ozone insufflation had a positive effect on surgical wound healing in acute period.
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spelling The acute effects of preoperative ozone theraphy on surgical wound healingOzoneWound HealingRabbitsABSTRACT PURPOSE: To investigate the effects of preoperative rectal ozone insufflation on surgical wound healing over the proinflammatory cytokines and histopathological changes. METHODS: Twenty one rabbits were divided into 3 groups. Sham, surgical wound, and ozone applied (6 sessions, every other day 70 µg/mL in 12 mL O2-O3 mixture rectally) surgical wound groups were created. TNF-alpha and IL-6 levels from all rabbits were studied at the basal, 24th hour, and 72nd hour. The histopathological examination was done by removing the surgical scar tissue at the end of 72nd hour. RESULTS: TNF-alfa and IL-6 levels were significantly lower compared to the control group, in the rabbits treated with ozone. The increase in angiogenesis, the decrease in the number of inflammatory cells, epidermal and dermal regeneration, better collagen deposition, and increased keratinisation in stratum corneum were observed in the histopathological examination. It was determined that the wound healing noticeably accelerated in the ozone group. CONCLUSION: Preoperative rectal ozone insufflation had a positive effect on surgical wound healing in acute period.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000700472Acta Cirúrgica Brasileira v.31 n.7 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020160070000007info:eu-repo/semantics/openAccessSahin,HasanSimsek,TuncerTurkon,HakanKalkan,YıldırayOzkul,FarukOzkan,M Turgut AlperErbas,MesutAltinisik,UgurDemiraran,Yavuzeng2016-08-24T00:00:00Zoai:scielo:S0102-86502016000700472Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2016-08-24T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv The acute effects of preoperative ozone theraphy on surgical wound healing
title The acute effects of preoperative ozone theraphy on surgical wound healing
spellingShingle The acute effects of preoperative ozone theraphy on surgical wound healing
Sahin,Hasan
Ozone
Wound Healing
Rabbits
title_short The acute effects of preoperative ozone theraphy on surgical wound healing
title_full The acute effects of preoperative ozone theraphy on surgical wound healing
title_fullStr The acute effects of preoperative ozone theraphy on surgical wound healing
title_full_unstemmed The acute effects of preoperative ozone theraphy on surgical wound healing
title_sort The acute effects of preoperative ozone theraphy on surgical wound healing
author Sahin,Hasan
author_facet Sahin,Hasan
Simsek,Tuncer
Turkon,Hakan
Kalkan,Yıldıray
Ozkul,Faruk
Ozkan,M Turgut Alper
Erbas,Mesut
Altinisik,Ugur
Demiraran,Yavuz
author_role author
author2 Simsek,Tuncer
Turkon,Hakan
Kalkan,Yıldıray
Ozkul,Faruk
Ozkan,M Turgut Alper
Erbas,Mesut
Altinisik,Ugur
Demiraran,Yavuz
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sahin,Hasan
Simsek,Tuncer
Turkon,Hakan
Kalkan,Yıldıray
Ozkul,Faruk
Ozkan,M Turgut Alper
Erbas,Mesut
Altinisik,Ugur
Demiraran,Yavuz
dc.subject.por.fl_str_mv Ozone
Wound Healing
Rabbits
topic Ozone
Wound Healing
Rabbits
description ABSTRACT PURPOSE: To investigate the effects of preoperative rectal ozone insufflation on surgical wound healing over the proinflammatory cytokines and histopathological changes. METHODS: Twenty one rabbits were divided into 3 groups. Sham, surgical wound, and ozone applied (6 sessions, every other day 70 µg/mL in 12 mL O2-O3 mixture rectally) surgical wound groups were created. TNF-alpha and IL-6 levels from all rabbits were studied at the basal, 24th hour, and 72nd hour. The histopathological examination was done by removing the surgical scar tissue at the end of 72nd hour. RESULTS: TNF-alfa and IL-6 levels were significantly lower compared to the control group, in the rabbits treated with ozone. The increase in angiogenesis, the decrease in the number of inflammatory cells, epidermal and dermal regeneration, better collagen deposition, and increased keratinisation in stratum corneum were observed in the histopathological examination. It was determined that the wound healing noticeably accelerated in the ozone group. CONCLUSION: Preoperative rectal ozone insufflation had a positive effect on surgical wound healing in acute period.
publishDate 2016
dc.date.none.fl_str_mv 2016-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000700472
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000700472
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-865020160070000007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.31 n.7 2016
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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