Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010 |
Resumo: | INTRODUCTION: High blood pressure is a systemic disease which has major clinical and psycho-social repercussions, involves a high morbidity-mortality rate and generates high costs for the health system. Its treatment involves the use of antihypertensive drugs, which are commercialized as trademark, generic or similar drugs. PURPOSE: To verify the antihypertensive effect produced by a similar dose of different trademarks of enalapril maleate in spontaneously hypertensive rats (SHR). METHODS: Fifteen mg/kg of enalapril maleate were administered by gavage in 50 SHR rats and their blood pressure was verified through tail plethysmography every three days in a period of 16 days. RESULTS: The group treated with reference drug has shown a significant reduction on blood pressure levels when compared to the control group. Thus, treatments with enalapril maleate of generic, similar-A and similar-B brands have also shown significant reduction on animals' blood pressure. CONCLUSION: The use of generic drug and similars (A and B) drugs in the same doses and for the same period of time has not shown significant difference regarding the reference drug, which suggests that the brands tested are bioequivalent. |
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Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive ratsHypertensionDrugs, GenericTherapeutic EquivalencyRatsINTRODUCTION: High blood pressure is a systemic disease which has major clinical and psycho-social repercussions, involves a high morbidity-mortality rate and generates high costs for the health system. Its treatment involves the use of antihypertensive drugs, which are commercialized as trademark, generic or similar drugs. PURPOSE: To verify the antihypertensive effect produced by a similar dose of different trademarks of enalapril maleate in spontaneously hypertensive rats (SHR). METHODS: Fifteen mg/kg of enalapril maleate were administered by gavage in 50 SHR rats and their blood pressure was verified through tail plethysmography every three days in a period of 16 days. RESULTS: The group treated with reference drug has shown a significant reduction on blood pressure levels when compared to the control group. Thus, treatments with enalapril maleate of generic, similar-A and similar-B brands have also shown significant reduction on animals' blood pressure. CONCLUSION: The use of generic drug and similars (A and B) drugs in the same doses and for the same period of time has not shown significant difference regarding the reference drug, which suggests that the brands tested are bioequivalent.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010Acta Cirúrgica Brasileira v.23 n.2 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000200010info:eu-repo/semantics/openAccessBaracho,Nilo César do ValeArruda,Guilherme D'Andréa SabaAlves,Lidinei JoséCarneiro,Márcio Felipe SalomonSiqueira,Matheus Teodoro GriloArango,Héctor GustavoReis,José Marcos doseng2008-03-26T00:00:00Zoai:scielo:S0102-86502008000200010Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-03-26T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats |
title |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats |
spellingShingle |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats Baracho,Nilo César do Vale Hypertension Drugs, Generic Therapeutic Equivalency Rats |
title_short |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats |
title_full |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats |
title_fullStr |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats |
title_full_unstemmed |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats |
title_sort |
Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats |
author |
Baracho,Nilo César do Vale |
author_facet |
Baracho,Nilo César do Vale Arruda,Guilherme D'Andréa Saba Alves,Lidinei José Carneiro,Márcio Felipe Salomon Siqueira,Matheus Teodoro Grilo Arango,Héctor Gustavo Reis,José Marcos dos |
author_role |
author |
author2 |
Arruda,Guilherme D'Andréa Saba Alves,Lidinei José Carneiro,Márcio Felipe Salomon Siqueira,Matheus Teodoro Grilo Arango,Héctor Gustavo Reis,José Marcos dos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Baracho,Nilo César do Vale Arruda,Guilherme D'Andréa Saba Alves,Lidinei José Carneiro,Márcio Felipe Salomon Siqueira,Matheus Teodoro Grilo Arango,Héctor Gustavo Reis,José Marcos dos |
dc.subject.por.fl_str_mv |
Hypertension Drugs, Generic Therapeutic Equivalency Rats |
topic |
Hypertension Drugs, Generic Therapeutic Equivalency Rats |
description |
INTRODUCTION: High blood pressure is a systemic disease which has major clinical and psycho-social repercussions, involves a high morbidity-mortality rate and generates high costs for the health system. Its treatment involves the use of antihypertensive drugs, which are commercialized as trademark, generic or similar drugs. PURPOSE: To verify the antihypertensive effect produced by a similar dose of different trademarks of enalapril maleate in spontaneously hypertensive rats (SHR). METHODS: Fifteen mg/kg of enalapril maleate were administered by gavage in 50 SHR rats and their blood pressure was verified through tail plethysmography every three days in a period of 16 days. RESULTS: The group treated with reference drug has shown a significant reduction on blood pressure levels when compared to the control group. Thus, treatments with enalapril maleate of generic, similar-A and similar-B brands have also shown significant reduction on animals' blood pressure. CONCLUSION: The use of generic drug and similars (A and B) drugs in the same doses and for the same period of time has not shown significant difference regarding the reference drug, which suggests that the brands tested are bioequivalent. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502008000200010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.23 n.2 2008 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126439090552832 |