Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats

Detalhes bibliográficos
Autor(a) principal: Baracho,Nilo César do Vale
Data de Publicação: 2008
Outros Autores: Arruda,Guilherme D'Andréa Saba, Alves,Lidinei José, Carneiro,Márcio Felipe Salomon, Siqueira,Matheus Teodoro Grilo, Arango,Héctor Gustavo, Reis,José Marcos dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010
Resumo: INTRODUCTION: High blood pressure is a systemic disease which has major clinical and psycho-social repercussions, involves a high morbidity-mortality rate and generates high costs for the health system. Its treatment involves the use of antihypertensive drugs, which are commercialized as trademark, generic or similar drugs. PURPOSE: To verify the antihypertensive effect produced by a similar dose of different trademarks of enalapril maleate in spontaneously hypertensive rats (SHR). METHODS: Fifteen mg/kg of enalapril maleate were administered by gavage in 50 SHR rats and their blood pressure was verified through tail plethysmography every three days in a period of 16 days. RESULTS: The group treated with reference drug has shown a significant reduction on blood pressure levels when compared to the control group. Thus, treatments with enalapril maleate of generic, similar-A and similar-B brands have also shown significant reduction on animals' blood pressure. CONCLUSION: The use of generic drug and similars (A and B) drugs in the same doses and for the same period of time has not shown significant difference regarding the reference drug, which suggests that the brands tested are bioequivalent.
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spelling Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive ratsHypertensionDrugs, GenericTherapeutic EquivalencyRatsINTRODUCTION: High blood pressure is a systemic disease which has major clinical and psycho-social repercussions, involves a high morbidity-mortality rate and generates high costs for the health system. Its treatment involves the use of antihypertensive drugs, which are commercialized as trademark, generic or similar drugs. PURPOSE: To verify the antihypertensive effect produced by a similar dose of different trademarks of enalapril maleate in spontaneously hypertensive rats (SHR). METHODS: Fifteen mg/kg of enalapril maleate were administered by gavage in 50 SHR rats and their blood pressure was verified through tail plethysmography every three days in a period of 16 days. RESULTS: The group treated with reference drug has shown a significant reduction on blood pressure levels when compared to the control group. Thus, treatments with enalapril maleate of generic, similar-A and similar-B brands have also shown significant reduction on animals' blood pressure. CONCLUSION: The use of generic drug and similars (A and B) drugs in the same doses and for the same period of time has not shown significant difference regarding the reference drug, which suggests that the brands tested are bioequivalent.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010Acta Cirúrgica Brasileira v.23 n.2 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000200010info:eu-repo/semantics/openAccessBaracho,Nilo César do ValeArruda,Guilherme D'Andréa SabaAlves,Lidinei JoséCarneiro,Márcio Felipe SalomonSiqueira,Matheus Teodoro GriloArango,Héctor GustavoReis,José Marcos doseng2008-03-26T00:00:00Zoai:scielo:S0102-86502008000200010Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-03-26T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
title Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
spellingShingle Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
Baracho,Nilo César do Vale
Hypertension
Drugs, Generic
Therapeutic Equivalency
Rats
title_short Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
title_full Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
title_fullStr Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
title_full_unstemmed Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
title_sort Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats
author Baracho,Nilo César do Vale
author_facet Baracho,Nilo César do Vale
Arruda,Guilherme D'Andréa Saba
Alves,Lidinei José
Carneiro,Márcio Felipe Salomon
Siqueira,Matheus Teodoro Grilo
Arango,Héctor Gustavo
Reis,José Marcos dos
author_role author
author2 Arruda,Guilherme D'Andréa Saba
Alves,Lidinei José
Carneiro,Márcio Felipe Salomon
Siqueira,Matheus Teodoro Grilo
Arango,Héctor Gustavo
Reis,José Marcos dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baracho,Nilo César do Vale
Arruda,Guilherme D'Andréa Saba
Alves,Lidinei José
Carneiro,Márcio Felipe Salomon
Siqueira,Matheus Teodoro Grilo
Arango,Héctor Gustavo
Reis,José Marcos dos
dc.subject.por.fl_str_mv Hypertension
Drugs, Generic
Therapeutic Equivalency
Rats
topic Hypertension
Drugs, Generic
Therapeutic Equivalency
Rats
description INTRODUCTION: High blood pressure is a systemic disease which has major clinical and psycho-social repercussions, involves a high morbidity-mortality rate and generates high costs for the health system. Its treatment involves the use of antihypertensive drugs, which are commercialized as trademark, generic or similar drugs. PURPOSE: To verify the antihypertensive effect produced by a similar dose of different trademarks of enalapril maleate in spontaneously hypertensive rats (SHR). METHODS: Fifteen mg/kg of enalapril maleate were administered by gavage in 50 SHR rats and their blood pressure was verified through tail plethysmography every three days in a period of 16 days. RESULTS: The group treated with reference drug has shown a significant reduction on blood pressure levels when compared to the control group. Thus, treatments with enalapril maleate of generic, similar-A and similar-B brands have also shown significant reduction on animals' blood pressure. CONCLUSION: The use of generic drug and similars (A and B) drugs in the same doses and for the same period of time has not shown significant difference regarding the reference drug, which suggests that the brands tested are bioequivalent.
publishDate 2008
dc.date.none.fl_str_mv 2008-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502008000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.23 n.2 2008
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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