Bone repair in rats treated with sodic diclofenac and calcitonin
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000010 |
Resumo: | PURPOSE: To investigate clinical and histologically the bone repair in treated animals with calcitonin and sodic diclofenac. METHODS: Ninety-six femoral defects were created in forty-eight animals distributed in four groups (n=24): either left untreated, treated with the sodic diclofenac or calcitonin or both. Follow-up was 7, 14 and 21 days. Histological sections stained by haematoxylin-eosin was observed under light microscopy (100X) and quantitatively scored for their trabecular formation. The groups and subgroups were compared being used the Kruskall-Wallis test. RESULTS: Smaller trabecular formation was observed in the animals of the group II and larger trabecular formation in the animals of the group III. Was found significant differences in the comparison between all the groups (Kruskall-Wallis, p <0.05). CONCLUSION: The obtained data suggest that the bone repair is a time-dependent process, which can be delayed by the sodic diclofenac and accelerated by the calcitonina, when used separately. The associated use of calcitonina and sodic diclofenac didn't show to be the best therapeutic option in the treatment of bone defects surgically created. |
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Acta Cirúrgica Brasileira (Online) |
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Bone repair in rats treated with sodic diclofenac and calcitoninOsteogenesisAnti-inflammatory agentsCalcitoninRatsPURPOSE: To investigate clinical and histologically the bone repair in treated animals with calcitonin and sodic diclofenac. METHODS: Ninety-six femoral defects were created in forty-eight animals distributed in four groups (n=24): either left untreated, treated with the sodic diclofenac or calcitonin or both. Follow-up was 7, 14 and 21 days. Histological sections stained by haematoxylin-eosin was observed under light microscopy (100X) and quantitatively scored for their trabecular formation. The groups and subgroups were compared being used the Kruskall-Wallis test. RESULTS: Smaller trabecular formation was observed in the animals of the group II and larger trabecular formation in the animals of the group III. Was found significant differences in the comparison between all the groups (Kruskall-Wallis, p <0.05). CONCLUSION: The obtained data suggest that the bone repair is a time-dependent process, which can be delayed by the sodic diclofenac and accelerated by the calcitonina, when used separately. The associated use of calcitonina and sodic diclofenac didn't show to be the best therapeutic option in the treatment of bone defects surgically created.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2006-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000010Acta Cirúrgica Brasileira v.21 suppl.4 2006reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502006001000010info:eu-repo/semantics/openAccessSassioto,Maria Cristina PitaInouye,Celso MassaschiAydos,Ricardo DutraFigueiredo,Arthur Silveira deeng2007-02-07T00:00:00Zoai:scielo:S0102-86502006001000010Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-02-07T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Bone repair in rats treated with sodic diclofenac and calcitonin |
title |
Bone repair in rats treated with sodic diclofenac and calcitonin |
spellingShingle |
Bone repair in rats treated with sodic diclofenac and calcitonin Sassioto,Maria Cristina Pita Osteogenesis Anti-inflammatory agents Calcitonin Rats |
title_short |
Bone repair in rats treated with sodic diclofenac and calcitonin |
title_full |
Bone repair in rats treated with sodic diclofenac and calcitonin |
title_fullStr |
Bone repair in rats treated with sodic diclofenac and calcitonin |
title_full_unstemmed |
Bone repair in rats treated with sodic diclofenac and calcitonin |
title_sort |
Bone repair in rats treated with sodic diclofenac and calcitonin |
author |
Sassioto,Maria Cristina Pita |
author_facet |
Sassioto,Maria Cristina Pita Inouye,Celso Massaschi Aydos,Ricardo Dutra Figueiredo,Arthur Silveira de |
author_role |
author |
author2 |
Inouye,Celso Massaschi Aydos,Ricardo Dutra Figueiredo,Arthur Silveira de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sassioto,Maria Cristina Pita Inouye,Celso Massaschi Aydos,Ricardo Dutra Figueiredo,Arthur Silveira de |
dc.subject.por.fl_str_mv |
Osteogenesis Anti-inflammatory agents Calcitonin Rats |
topic |
Osteogenesis Anti-inflammatory agents Calcitonin Rats |
description |
PURPOSE: To investigate clinical and histologically the bone repair in treated animals with calcitonin and sodic diclofenac. METHODS: Ninety-six femoral defects were created in forty-eight animals distributed in four groups (n=24): either left untreated, treated with the sodic diclofenac or calcitonin or both. Follow-up was 7, 14 and 21 days. Histological sections stained by haematoxylin-eosin was observed under light microscopy (100X) and quantitatively scored for their trabecular formation. The groups and subgroups were compared being used the Kruskall-Wallis test. RESULTS: Smaller trabecular formation was observed in the animals of the group II and larger trabecular formation in the animals of the group III. Was found significant differences in the comparison between all the groups (Kruskall-Wallis, p <0.05). CONCLUSION: The obtained data suggest that the bone repair is a time-dependent process, which can be delayed by the sodic diclofenac and accelerated by the calcitonina, when used separately. The associated use of calcitonina and sodic diclofenac didn't show to be the best therapeutic option in the treatment of bone defects surgically created. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006001000010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502006001000010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.21 suppl.4 2006 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
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1752126438571507712 |