Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/41976 http://dx.doi.org/10.1590/S0102-86502008000200006 |
Resumo: | Purpose: To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Methods: Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had the bone defect filled with autograft and those of Group II, with bovine bone devitalized matrix. Animals of each group were redistributed to four subgroups according to the intramuscular administration of anti-inflammatory drug or saline solution: A - diclofenac sodium; B - dexamethasone; C - meloxicam; D - saline solution. Evaluation periods were 7, 14 and 30 days. Histological evaluation consisted of quantifying the inflammatory process, the bone neoformation, the collagen formation and the presence of macrophages. Results: Animals of Group I did not show significant difference considering inflammatory reaction. Significant and progressive increase of bone neoformation was observed in both groups. The animals that received meloxicam and autograft showed less collagen formation at 14 and 30 days. The number of macrophages was higher in Group II than in Group I. The animals treated with dexamethasone and saline Solution did not show statistically significant difference. Conclusions: Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it. |
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Silva, Roberto Antoniolli da [UNIFESP]Fagundes, Djalma José [UNIFESP]Silva, Andreia Conceicao Milan Brochado AntoniolliSisti, Karin EllenCarvalho, Themis Maria Milan Brochado deSilva, Daniel Nunes eUniversidade Federal de Mato Grosso do Sul (UFMS)Universidade Federal de São Paulo (UNIFESP)2018-06-15T11:14:55Z2018-06-15T11:14:55Z2008-03-01Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 140-148, 2008.0102-8650http://repositorio.unifesp.br/11600/41976http://dx.doi.org/10.1590/S0102-86502008000200006S0102-86502008000200006.pdfS0102-8650200800020000610.1590/S0102-86502008000200006WOS:000258661800006Purpose: To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Methods: Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had the bone defect filled with autograft and those of Group II, with bovine bone devitalized matrix. Animals of each group were redistributed to four subgroups according to the intramuscular administration of anti-inflammatory drug or saline solution: A - diclofenac sodium; B - dexamethasone; C - meloxicam; D - saline solution. Evaluation periods were 7, 14 and 30 days. Histological evaluation consisted of quantifying the inflammatory process, the bone neoformation, the collagen formation and the presence of macrophages. Results: Animals of Group I did not show significant difference considering inflammatory reaction. Significant and progressive increase of bone neoformation was observed in both groups. The animals that received meloxicam and autograft showed less collagen formation at 14 and 30 days. The number of macrophages was higher in Group II than in Group I. The animals treated with dexamethasone and saline Solution did not show statistically significant difference. Conclusions: Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it.Fed Univ Mato Grosso do Sul UFMS, Dept Surg Clin, Mato Grosso, BrazilUniv Fed Sao Paulo UNIFESP, Sch Med, Postgrad Program Surg & Experimentat, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Sch Med, Postgrad Program Surg & Experimentat, Sao Paulo, BrazilWeb of Science140-148engActa Cirurgica BrasileiraActa Cirurgica Brasileirabone transplantationanti-inflammatory agentsrats, wistarEffect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in ratsEfeito de antiinflamatórios na integração de enxerto ósseo autógeno e de matriz óssea bovina desvitalizada em ratosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/419762021-09-30 11:04:15.03metadata only accessoai:repositorio.unifesp.br:11600/41976Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-30T14:04:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats |
dc.title.alternative.pt.fl_str_mv |
Efeito de antiinflamatórios na integração de enxerto ósseo autógeno e de matriz óssea bovina desvitalizada em ratos |
title |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats |
spellingShingle |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats Silva, Roberto Antoniolli da [UNIFESP] bone transplantation anti-inflammatory agents rats, wistar |
title_short |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats |
title_full |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats |
title_fullStr |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats |
title_full_unstemmed |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats |
title_sort |
Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats |
author |
Silva, Roberto Antoniolli da [UNIFESP] |
author_facet |
Silva, Roberto Antoniolli da [UNIFESP] Fagundes, Djalma José [UNIFESP] Silva, Andreia Conceicao Milan Brochado Antoniolli Sisti, Karin Ellen Carvalho, Themis Maria Milan Brochado de Silva, Daniel Nunes e |
author_role |
author |
author2 |
Fagundes, Djalma José [UNIFESP] Silva, Andreia Conceicao Milan Brochado Antoniolli Sisti, Karin Ellen Carvalho, Themis Maria Milan Brochado de Silva, Daniel Nunes e |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de Mato Grosso do Sul (UFMS) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Silva, Roberto Antoniolli da [UNIFESP] Fagundes, Djalma José [UNIFESP] Silva, Andreia Conceicao Milan Brochado Antoniolli Sisti, Karin Ellen Carvalho, Themis Maria Milan Brochado de Silva, Daniel Nunes e |
dc.subject.eng.fl_str_mv |
bone transplantation anti-inflammatory agents rats, wistar |
topic |
bone transplantation anti-inflammatory agents rats, wistar |
description |
Purpose: To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Methods: Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had the bone defect filled with autograft and those of Group II, with bovine bone devitalized matrix. Animals of each group were redistributed to four subgroups according to the intramuscular administration of anti-inflammatory drug or saline solution: A - diclofenac sodium; B - dexamethasone; C - meloxicam; D - saline solution. Evaluation periods were 7, 14 and 30 days. Histological evaluation consisted of quantifying the inflammatory process, the bone neoformation, the collagen formation and the presence of macrophages. Results: Animals of Group I did not show significant difference considering inflammatory reaction. Significant and progressive increase of bone neoformation was observed in both groups. The animals that received meloxicam and autograft showed less collagen formation at 14 and 30 days. The number of macrophages was higher in Group II than in Group I. The animals treated with dexamethasone and saline Solution did not show statistically significant difference. Conclusions: Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-03-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T11:14:55Z |
dc.date.available.fl_str_mv |
2018-06-15T11:14:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 140-148, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/41976 http://dx.doi.org/10.1590/S0102-86502008000200006 |
dc.identifier.issn.none.fl_str_mv |
0102-8650 |
dc.identifier.file.none.fl_str_mv |
S0102-86502008000200006.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0102-86502008000200006 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0102-86502008000200006 |
dc.identifier.wos.none.fl_str_mv |
WOS:000258661800006 |
identifier_str_mv |
Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 140-148, 2008. 0102-8650 S0102-86502008000200006.pdf S0102-86502008000200006 10.1590/S0102-86502008000200006 WOS:000258661800006 |
url |
http://repositorio.unifesp.br/11600/41976 http://dx.doi.org/10.1590/S0102-86502008000200006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
140-148 |
dc.publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764115908755456 |