Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats

Detalhes bibliográficos
Autor(a) principal: Menezes,Honório Sampaio
Data de Publicação: 2009
Outros Autores: Ciulla,Verônica, Camargo,Paulo Sampaio, Correa,Cora Albrecht, Oliveira,Tatiana Medina Costa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000600006
Resumo: PURPOSE: To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine. METHODS: It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats, adults females with a hyper caloric diet. We collected their blood 3 times and weighted them once a week. We divided the rats in 3 groups: Rimonabant, Sibutramine and Control. Statistic analysis has been made through ANOVA test, Tukey test and t Student test. RESULTS: The Rimonabant group demonstrated a significant reduction of the weight increase in rats. The Sibutramine group showed a significant reduction on blood glycemia compared to Rimonabant group and Control group. CONCLUSIONS: Rimonabant showed to be more effective than Sibutramine by decreasing weight gain. Sibutramine has been more effective than Rimonabant and Control groups by decreasing the blood glycemia.
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spelling Comparison of rimonabant and sibutramine treatment effects on food compulsion in ratsObesityDrug EffectsAnimal ExperimentationRatsPURPOSE: To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine. METHODS: It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats, adults females with a hyper caloric diet. We collected their blood 3 times and weighted them once a week. We divided the rats in 3 groups: Rimonabant, Sibutramine and Control. Statistic analysis has been made through ANOVA test, Tukey test and t Student test. RESULTS: The Rimonabant group demonstrated a significant reduction of the weight increase in rats. The Sibutramine group showed a significant reduction on blood glycemia compared to Rimonabant group and Control group. CONCLUSIONS: Rimonabant showed to be more effective than Sibutramine by decreasing weight gain. Sibutramine has been more effective than Rimonabant and Control groups by decreasing the blood glycemia.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000600006Acta Cirúrgica Brasileira v.24 n.6 2009reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502009000600006info:eu-repo/semantics/openAccessMenezes,Honório SampaioCiulla,VerônicaCamargo,Paulo SampaioCorrea,Cora AlbrechtOliveira,Tatiana Medina Costa deeng2009-12-10T00:00:00Zoai:scielo:S0102-86502009000600006Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2009-12-10T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
title Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
spellingShingle Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
Menezes,Honório Sampaio
Obesity
Drug Effects
Animal Experimentation
Rats
title_short Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
title_full Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
title_fullStr Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
title_full_unstemmed Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
title_sort Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats
author Menezes,Honório Sampaio
author_facet Menezes,Honório Sampaio
Ciulla,Verônica
Camargo,Paulo Sampaio
Correa,Cora Albrecht
Oliveira,Tatiana Medina Costa de
author_role author
author2 Ciulla,Verônica
Camargo,Paulo Sampaio
Correa,Cora Albrecht
Oliveira,Tatiana Medina Costa de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Menezes,Honório Sampaio
Ciulla,Verônica
Camargo,Paulo Sampaio
Correa,Cora Albrecht
Oliveira,Tatiana Medina Costa de
dc.subject.por.fl_str_mv Obesity
Drug Effects
Animal Experimentation
Rats
topic Obesity
Drug Effects
Animal Experimentation
Rats
description PURPOSE: To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine. METHODS: It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats, adults females with a hyper caloric diet. We collected their blood 3 times and weighted them once a week. We divided the rats in 3 groups: Rimonabant, Sibutramine and Control. Statistic analysis has been made through ANOVA test, Tukey test and t Student test. RESULTS: The Rimonabant group demonstrated a significant reduction of the weight increase in rats. The Sibutramine group showed a significant reduction on blood glycemia compared to Rimonabant group and Control group. CONCLUSIONS: Rimonabant showed to be more effective than Sibutramine by decreasing weight gain. Sibutramine has been more effective than Rimonabant and Control groups by decreasing the blood glycemia.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000600006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000600006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502009000600006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.24 n.6 2009
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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