Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test

Detalhes bibliográficos
Autor(a) principal: Menezes,Honório Sampaio
Data de Publicação: 2008
Outros Autores: Bueno,Bárbara Beatriz Moreira, Ciulla,Leandro, Schuh,Alexandre, Luz,Fernanda de Freitas, Alves,Rafael José Vargas, Abegg,Milena Pacheco, Cirino,Sílvia Letícia Merceo Bacchi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000500010
Resumo: PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION: Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.
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spelling Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming testPhysiological Effects of DrugsDepressionAnimal ExperimentationRatsPURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION: Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2008-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000500010Acta Cirúrgica Brasileira v.23 n.5 2008reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502008000500010info:eu-repo/semantics/openAccessMenezes,Honório SampaioBueno,Bárbara Beatriz MoreiraCiulla,LeandroSchuh,AlexandreLuz,Fernanda de FreitasAlves,Rafael José VargasAbegg,Milena PachecoCirino,Sílvia Letícia Merceo Bacchieng2008-09-03T00:00:00Zoai:scielo:S0102-86502008000500010Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-09-03T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
title Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
spellingShingle Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
Menezes,Honório Sampaio
Physiological Effects of Drugs
Depression
Animal Experimentation
Rats
title_short Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
title_full Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
title_fullStr Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
title_full_unstemmed Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
title_sort Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test
author Menezes,Honório Sampaio
author_facet Menezes,Honório Sampaio
Bueno,Bárbara Beatriz Moreira
Ciulla,Leandro
Schuh,Alexandre
Luz,Fernanda de Freitas
Alves,Rafael José Vargas
Abegg,Milena Pacheco
Cirino,Sílvia Letícia Merceo Bacchi
author_role author
author2 Bueno,Bárbara Beatriz Moreira
Ciulla,Leandro
Schuh,Alexandre
Luz,Fernanda de Freitas
Alves,Rafael José Vargas
Abegg,Milena Pacheco
Cirino,Sílvia Letícia Merceo Bacchi
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Menezes,Honório Sampaio
Bueno,Bárbara Beatriz Moreira
Ciulla,Leandro
Schuh,Alexandre
Luz,Fernanda de Freitas
Alves,Rafael José Vargas
Abegg,Milena Pacheco
Cirino,Sílvia Letícia Merceo Bacchi
dc.subject.por.fl_str_mv Physiological Effects of Drugs
Depression
Animal Experimentation
Rats
topic Physiological Effects of Drugs
Depression
Animal Experimentation
Rats
description PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION: Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.
publishDate 2008
dc.date.none.fl_str_mv 2008-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000500010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000500010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502008000500010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.23 n.5 2008
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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