Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats

• Autor(a) principal: Bernardes,Milton Junior Cândido
• Data de Publicação: 2022
• Outros Autores: Gonçalves,Randys Caldeira, Carvalho,Carolyna de Sousa, Rosa,Luciana Martins, Ferreira,Amanda Peixoto, Vilela,Marielle Sousa, Vinaud,Marina Clare, Galdino Junior,Hélio, Lino Junior,Ruy de Souza
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Cirúrgica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000400204
• topic: Burns; Wound Healing; Hydrogels; Rats

ABSTRACT Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats. Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed. Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05). Conclusions: The hydrogel-based dressings presented beneficial outcomes in the healing of burn wounds experimentally induced in rats due to their ability in maintain the humidity of the wound, in removing the exudate, in promoting cell migration and collagen production during the different phases of the healing process.