Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations

Detalhes bibliográficos
Autor(a) principal: Macedo,Maurício
Data de Publicação: 2007
Outros Autores: Martins,José Luiz, Meyer,Karine Furtado, Soares,Iberê Cauduro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000600005
Resumo: PURPOSE: To study the ganglion cells (GC) in the terminal bowel of rats with ethylenethiourea (ETU) induced anorectal malformations (ARM). METHODS: The animals were divided into three groups: Group A - normal fetuses from pregnant rats that were not administered ETU; Group B - fetuses without ARM born from pregnant rats that were administered ETU and Group C - fetuses with ARM born from pregnant rats that received ETU. ETU was administered on the 11th day of pregnancy at the dose of 125 mg/kg body weight by gastric gavage. The rats had cesarean section on the 21st day of gestation. The fetuses’ terminal bowel tissue was analyzed by immunohistochemistry to demonstrate ganglion cells. RESULTS: Statistically significant differences were found between groups A, B and C regarding ganglion cell densities. Group A had the highest cell density, followed by Group B and the lowest density was found in Group C. CONCLUSION: Ganglion cell densities are decreased in the terminal bowel of rats with ARM.
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spelling Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformationsAnus, ImperforateConstipationEthylenethioureaS100 proteinEnteric Nervous SystemRatsPURPOSE: To study the ganglion cells (GC) in the terminal bowel of rats with ethylenethiourea (ETU) induced anorectal malformations (ARM). METHODS: The animals were divided into three groups: Group A - normal fetuses from pregnant rats that were not administered ETU; Group B - fetuses without ARM born from pregnant rats that were administered ETU and Group C - fetuses with ARM born from pregnant rats that received ETU. ETU was administered on the 11th day of pregnancy at the dose of 125 mg/kg body weight by gastric gavage. The rats had cesarean section on the 21st day of gestation. The fetuses’ terminal bowel tissue was analyzed by immunohistochemistry to demonstrate ganglion cells. RESULTS: Statistically significant differences were found between groups A, B and C regarding ganglion cell densities. Group A had the highest cell density, followed by Group B and the lowest density was found in Group C. CONCLUSION: Ganglion cell densities are decreased in the terminal bowel of rats with ARM.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000600005Acta Cirúrgica Brasileira v.22 n.6 2007reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502007000600005info:eu-repo/semantics/openAccessMacedo,MaurícioMartins,José LuizMeyer,Karine FurtadoSoares,Iberê Cauduroeng2008-01-22T00:00:00Zoai:scielo:S0102-86502007000600005Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2008-01-22T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
title Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
spellingShingle Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
Macedo,Maurício
Anus, Imperforate
Constipation
Ethylenethiourea
S100 protein
Enteric Nervous System
Rats
title_short Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
title_full Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
title_fullStr Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
title_full_unstemmed Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
title_sort Study of the density of ganglion cells in the terminal bowel of rats with anorectal malformations
author Macedo,Maurício
author_facet Macedo,Maurício
Martins,José Luiz
Meyer,Karine Furtado
Soares,Iberê Cauduro
author_role author
author2 Martins,José Luiz
Meyer,Karine Furtado
Soares,Iberê Cauduro
author2_role author
author
author
dc.contributor.author.fl_str_mv Macedo,Maurício
Martins,José Luiz
Meyer,Karine Furtado
Soares,Iberê Cauduro
dc.subject.por.fl_str_mv Anus, Imperforate
Constipation
Ethylenethiourea
S100 protein
Enteric Nervous System
Rats
topic Anus, Imperforate
Constipation
Ethylenethiourea
S100 protein
Enteric Nervous System
Rats
description PURPOSE: To study the ganglion cells (GC) in the terminal bowel of rats with ethylenethiourea (ETU) induced anorectal malformations (ARM). METHODS: The animals were divided into three groups: Group A - normal fetuses from pregnant rats that were not administered ETU; Group B - fetuses without ARM born from pregnant rats that were administered ETU and Group C - fetuses with ARM born from pregnant rats that received ETU. ETU was administered on the 11th day of pregnancy at the dose of 125 mg/kg body weight by gastric gavage. The rats had cesarean section on the 21st day of gestation. The fetuses’ terminal bowel tissue was analyzed by immunohistochemistry to demonstrate ganglion cells. RESULTS: Statistically significant differences were found between groups A, B and C regarding ganglion cell densities. Group A had the highest cell density, followed by Group B and the lowest density was found in Group C. CONCLUSION: Ganglion cell densities are decreased in the terminal bowel of rats with ARM.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000600005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000600005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502007000600005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.22 n.6 2007
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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