Pathophysiology of mesenteric ischemia/reperfusion: a review

Detalhes bibliográficos
Autor(a) principal: Cerqueira,Nereide Freire
Data de Publicação: 2005
Outros Autores: Hussni,Carlos Alberto, Yoshida,Winston Bonetti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000400013
Resumo: During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.
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spelling Pathophysiology of mesenteric ischemia/reperfusion: a reviewischemiareperfusionmesenteric vascular occlusionreperfusion injuryDuring ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2005-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000400013Acta Cirúrgica Brasileira v.20 n.4 2005reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502005000400013info:eu-repo/semantics/openAccessCerqueira,Nereide FreireHussni,Carlos AlbertoYoshida,Winston Bonettieng2005-07-20T00:00:00Zoai:scielo:S0102-86502005000400013Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2005-07-20T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Pathophysiology of mesenteric ischemia/reperfusion: a review
title Pathophysiology of mesenteric ischemia/reperfusion: a review
spellingShingle Pathophysiology of mesenteric ischemia/reperfusion: a review
Cerqueira,Nereide Freire
ischemia
reperfusion
mesenteric vascular occlusion
reperfusion injury
title_short Pathophysiology of mesenteric ischemia/reperfusion: a review
title_full Pathophysiology of mesenteric ischemia/reperfusion: a review
title_fullStr Pathophysiology of mesenteric ischemia/reperfusion: a review
title_full_unstemmed Pathophysiology of mesenteric ischemia/reperfusion: a review
title_sort Pathophysiology of mesenteric ischemia/reperfusion: a review
author Cerqueira,Nereide Freire
author_facet Cerqueira,Nereide Freire
Hussni,Carlos Alberto
Yoshida,Winston Bonetti
author_role author
author2 Hussni,Carlos Alberto
Yoshida,Winston Bonetti
author2_role author
author
dc.contributor.author.fl_str_mv Cerqueira,Nereide Freire
Hussni,Carlos Alberto
Yoshida,Winston Bonetti
dc.subject.por.fl_str_mv ischemia
reperfusion
mesenteric vascular occlusion
reperfusion injury
topic ischemia
reperfusion
mesenteric vascular occlusion
reperfusion injury
description During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.
publishDate 2005
dc.date.none.fl_str_mv 2005-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000400013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000400013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502005000400013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.20 n.4 2005
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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