Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome

Detalhes bibliográficos
Autor(a) principal: Nacif,Lucas Souto
Data de Publicação: 2014
Outros Autores: Andraus,Wellington, Kubrusly,Márcia Saldanha, Kubrusly,Flávia Saldanha, Gebara,Vera Cristina Bugelli Cainelli, Ishizawa,Andrea, D'Albuquerque,Luiz Augusto Carneiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573
Resumo: PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05.RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05).CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.
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spelling Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndromeHepatopulmonary SyndromePulmonary Surfactant-Associated Protein AModels, AnimalRatsPURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05.RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05).CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573Acta Cirúrgica Brasileira v.29 n.9 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-8650201400150004info:eu-repo/semantics/openAccessNacif,Lucas SoutoAndraus,WellingtonKubrusly,Márcia SaldanhaKubrusly,Flávia SaldanhaGebara,Vera Cristina Bugelli CainelliIshizawa,AndreaD'Albuquerque,Luiz Augusto Carneiroeng2015-10-27T00:00:00Zoai:scielo:S0102-86502014000900573Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
title Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
spellingShingle Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
Nacif,Lucas Souto
Hepatopulmonary Syndrome
Pulmonary Surfactant-Associated Protein A
Models, Animal
Rats
title_short Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
title_full Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
title_fullStr Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
title_full_unstemmed Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
title_sort Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
author Nacif,Lucas Souto
author_facet Nacif,Lucas Souto
Andraus,Wellington
Kubrusly,Márcia Saldanha
Kubrusly,Flávia Saldanha
Gebara,Vera Cristina Bugelli Cainelli
Ishizawa,Andrea
D'Albuquerque,Luiz Augusto Carneiro
author_role author
author2 Andraus,Wellington
Kubrusly,Márcia Saldanha
Kubrusly,Flávia Saldanha
Gebara,Vera Cristina Bugelli Cainelli
Ishizawa,Andrea
D'Albuquerque,Luiz Augusto Carneiro
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nacif,Lucas Souto
Andraus,Wellington
Kubrusly,Márcia Saldanha
Kubrusly,Flávia Saldanha
Gebara,Vera Cristina Bugelli Cainelli
Ishizawa,Andrea
D'Albuquerque,Luiz Augusto Carneiro
dc.subject.por.fl_str_mv Hepatopulmonary Syndrome
Pulmonary Surfactant-Associated Protein A
Models, Animal
Rats
topic Hepatopulmonary Syndrome
Pulmonary Surfactant-Associated Protein A
Models, Animal
Rats
description PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05.RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05).CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-8650201400150004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.29 n.9 2014
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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