Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573 |
Resumo: | PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05.RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05).CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response. |
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Acta Cirúrgica Brasileira (Online) |
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Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndromeHepatopulmonary SyndromePulmonary Surfactant-Associated Protein AModels, AnimalRatsPURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05.RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05).CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573Acta Cirúrgica Brasileira v.29 n.9 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-8650201400150004info:eu-repo/semantics/openAccessNacif,Lucas SoutoAndraus,WellingtonKubrusly,Márcia SaldanhaKubrusly,Flávia SaldanhaGebara,Vera Cristina Bugelli CainelliIshizawa,AndreaD'Albuquerque,Luiz Augusto Carneiroeng2015-10-27T00:00:00Zoai:scielo:S0102-86502014000900573Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome |
title |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome |
spellingShingle |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome Nacif,Lucas Souto Hepatopulmonary Syndrome Pulmonary Surfactant-Associated Protein A Models, Animal Rats |
title_short |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome |
title_full |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome |
title_fullStr |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome |
title_full_unstemmed |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome |
title_sort |
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome |
author |
Nacif,Lucas Souto |
author_facet |
Nacif,Lucas Souto Andraus,Wellington Kubrusly,Márcia Saldanha Kubrusly,Flávia Saldanha Gebara,Vera Cristina Bugelli Cainelli Ishizawa,Andrea D'Albuquerque,Luiz Augusto Carneiro |
author_role |
author |
author2 |
Andraus,Wellington Kubrusly,Márcia Saldanha Kubrusly,Flávia Saldanha Gebara,Vera Cristina Bugelli Cainelli Ishizawa,Andrea D'Albuquerque,Luiz Augusto Carneiro |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Nacif,Lucas Souto Andraus,Wellington Kubrusly,Márcia Saldanha Kubrusly,Flávia Saldanha Gebara,Vera Cristina Bugelli Cainelli Ishizawa,Andrea D'Albuquerque,Luiz Augusto Carneiro |
dc.subject.por.fl_str_mv |
Hepatopulmonary Syndrome Pulmonary Surfactant-Associated Protein A Models, Animal Rats |
topic |
Hepatopulmonary Syndrome Pulmonary Surfactant-Associated Protein A Models, Animal Rats |
description |
PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05.RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05).CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-8650201400150004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.29 n.9 2014 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442658856960 |