Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700010 |
Resumo: | PURPOSE: To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period. METHODS: Thirty Wistar rats were divided into three groups: control (C) - sham-operated, total splenectomy - isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and glucose (GLUC) were analyzed before the surgical procedure and after 6 and 12 weeks. RESULTS: All the animals presented significant increase of TG and VLDL levels. In relation to the other parameters there was no difference among the weeks 0 and 12 in the animals of group C. In TS group significant increase was observed in TC and GLUC levels during the experiment. In SA group TC, HDL, and GLUC levels remained unaffected while HDL levels increased. CONCLUSION: Our findings suggest that isolated total splenectomy alters lipids metabolism in rats fed with standard chow and splenic autotransplantation is effective in restoring its control. |
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Acta Cirúrgica Brasileira (Online) |
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Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplantSplenectomyTransplantationLipid metabolismAnimal feedPURPOSE: To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period. METHODS: Thirty Wistar rats were divided into three groups: control (C) - sham-operated, total splenectomy - isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and glucose (GLUC) were analyzed before the surgical procedure and after 6 and 12 weeks. RESULTS: All the animals presented significant increase of TG and VLDL levels. In relation to the other parameters there was no difference among the weeks 0 and 12 in the animals of group C. In TS group significant increase was observed in TC and GLUC levels during the experiment. In SA group TC, HDL, and GLUC levels remained unaffected while HDL levels increased. CONCLUSION: Our findings suggest that isolated total splenectomy alters lipids metabolism in rats fed with standard chow and splenic autotransplantation is effective in restoring its control.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700010Acta Cirúrgica Brasileira v.22 suppl.1 2007reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502007000700010info:eu-repo/semantics/openAccessSimões,Fernanda CorreiaMarques,Ruy GarciaDiestel,Cristina FajardoCaetano,Carlos Eduardo RodriguesDinis,Ana Paula GonçalvesHorst,Nara LimeiraNogueira Neto,José FirminoPortela,Margareth Crisóstomoeng2007-04-26T00:00:00Zoai:scielo:S0102-86502007000700010Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-04-26T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
spellingShingle |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant Simões,Fernanda Correia Splenectomy Transplantation Lipid metabolism Animal feed |
title_short |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_full |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_fullStr |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_full_unstemmed |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_sort |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
author |
Simões,Fernanda Correia |
author_facet |
Simões,Fernanda Correia Marques,Ruy Garcia Diestel,Cristina Fajardo Caetano,Carlos Eduardo Rodrigues Dinis,Ana Paula Gonçalves Horst,Nara Limeira Nogueira Neto,José Firmino Portela,Margareth Crisóstomo |
author_role |
author |
author2 |
Marques,Ruy Garcia Diestel,Cristina Fajardo Caetano,Carlos Eduardo Rodrigues Dinis,Ana Paula Gonçalves Horst,Nara Limeira Nogueira Neto,José Firmino Portela,Margareth Crisóstomo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Simões,Fernanda Correia Marques,Ruy Garcia Diestel,Cristina Fajardo Caetano,Carlos Eduardo Rodrigues Dinis,Ana Paula Gonçalves Horst,Nara Limeira Nogueira Neto,José Firmino Portela,Margareth Crisóstomo |
dc.subject.por.fl_str_mv |
Splenectomy Transplantation Lipid metabolism Animal feed |
topic |
Splenectomy Transplantation Lipid metabolism Animal feed |
description |
PURPOSE: To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period. METHODS: Thirty Wistar rats were divided into three groups: control (C) - sham-operated, total splenectomy - isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and glucose (GLUC) were analyzed before the surgical procedure and after 6 and 12 weeks. RESULTS: All the animals presented significant increase of TG and VLDL levels. In relation to the other parameters there was no difference among the weeks 0 and 12 in the animals of group C. In TS group significant increase was observed in TC and GLUC levels during the experiment. In SA group TC, HDL, and GLUC levels remained unaffected while HDL levels increased. CONCLUSION: Our findings suggest that isolated total splenectomy alters lipids metabolism in rats fed with standard chow and splenic autotransplantation is effective in restoring its control. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502007000700010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.22 suppl.1 2007 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126439031832576 |