Falsely elevated serum estradiol due to heterophile antibody interference: a case report

Detalhes bibliográficos
Autor(a) principal: Atkins,Paul
Data de Publicação: 2021
Outros Autores: Mattman,Andre, Thompson,David
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000200237
Resumo: SUMMARY Falsely elevated estradiol is rare, may result from heterophile antibody interference, and can result in unnecessary investigation and intervention. We present the case of a 56-year-old female with falsely elevated estradiol levels inconsistent with her overall clinical picture, which ultimately led to an unnecessary surgical procedure. With the use of alternative analytical platforms and a heterophile antibody blocking agent, we determined the false elevation was due to heterophile antibody interference. Clinicians must suspect and investigate for laboratory error when the clinical picture contradicts laboratory results.
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spelling Falsely elevated serum estradiol due to heterophile antibody interference: a case reportSUMMARY Falsely elevated estradiol is rare, may result from heterophile antibody interference, and can result in unnecessary investigation and intervention. We present the case of a 56-year-old female with falsely elevated estradiol levels inconsistent with her overall clinical picture, which ultimately led to an unnecessary surgical procedure. With the use of alternative analytical platforms and a heterophile antibody blocking agent, we determined the false elevation was due to heterophile antibody interference. Clinicians must suspect and investigate for laboratory error when the clinical picture contradicts laboratory results.Sociedade Brasileira de Endocrinologia e Metabologia2021-04-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000200237Archives of Endocrinology and Metabolism v.65 n.2 2021reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000324info:eu-repo/semantics/openAccessAtkins,PaulMattman,AndreThompson,Davideng2021-04-19T00:00:00Zoai:scielo:S2359-39972021000200237Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2021-04-19T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Falsely elevated serum estradiol due to heterophile antibody interference: a case report
title Falsely elevated serum estradiol due to heterophile antibody interference: a case report
spellingShingle Falsely elevated serum estradiol due to heterophile antibody interference: a case report
Atkins,Paul
title_short Falsely elevated serum estradiol due to heterophile antibody interference: a case report
title_full Falsely elevated serum estradiol due to heterophile antibody interference: a case report
title_fullStr Falsely elevated serum estradiol due to heterophile antibody interference: a case report
title_full_unstemmed Falsely elevated serum estradiol due to heterophile antibody interference: a case report
title_sort Falsely elevated serum estradiol due to heterophile antibody interference: a case report
author Atkins,Paul
author_facet Atkins,Paul
Mattman,Andre
Thompson,David
author_role author
author2 Mattman,Andre
Thompson,David
author2_role author
author
dc.contributor.author.fl_str_mv Atkins,Paul
Mattman,Andre
Thompson,David
description SUMMARY Falsely elevated estradiol is rare, may result from heterophile antibody interference, and can result in unnecessary investigation and intervention. We present the case of a 56-year-old female with falsely elevated estradiol levels inconsistent with her overall clinical picture, which ultimately led to an unnecessary surgical procedure. With the use of alternative analytical platforms and a heterophile antibody blocking agent, we determined the false elevation was due to heterophile antibody interference. Clinicians must suspect and investigate for laboratory error when the clinical picture contradicts laboratory results.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000200237
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000200237
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.20945/2359-3997000000324
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.65 n.2 2021
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
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reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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