Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de Endocrinologia e Metabolismo (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000300275 |
Resumo: | ABSTRACT Objectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice. |
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Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapyInflammationbone turnover markersobesityadolescentsweight lossABSTRACT Objectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice.Sociedade Brasileira de Endocrinologia e Metabologia2018-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000300275Archives of Endocrinology and Metabolism v.62 n.3 2018reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000039info:eu-repo/semantics/openAccessCampos,Raquel Munhoz da SilveiraMasquio,Deborah Cristina LandiCorgosinho,Flávia CamposCarvalho-Ferreira,Joana Pereira deMolin Netto,Bárbara DalClemente,Ana Paula GrottiTock,LianTufik,SergioMello,Marco Túlio deDâmaso,Ana Raimundaeng2018-06-26T00:00:00Zoai:scielo:S2359-39972018000300275Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2018-06-26T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
title |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
spellingShingle |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy Campos,Raquel Munhoz da Silveira Inflammation bone turnover markers obesity adolescents weight loss |
title_short |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
title_full |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
title_fullStr |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
title_full_unstemmed |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
title_sort |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
author |
Campos,Raquel Munhoz da Silveira |
author_facet |
Campos,Raquel Munhoz da Silveira Masquio,Deborah Cristina Landi Corgosinho,Flávia Campos Carvalho-Ferreira,Joana Pereira de Molin Netto,Bárbara Dal Clemente,Ana Paula Grotti Tock,Lian Tufik,Sergio Mello,Marco Túlio de Dâmaso,Ana Raimunda |
author_role |
author |
author2 |
Masquio,Deborah Cristina Landi Corgosinho,Flávia Campos Carvalho-Ferreira,Joana Pereira de Molin Netto,Bárbara Dal Clemente,Ana Paula Grotti Tock,Lian Tufik,Sergio Mello,Marco Túlio de Dâmaso,Ana Raimunda |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Campos,Raquel Munhoz da Silveira Masquio,Deborah Cristina Landi Corgosinho,Flávia Campos Carvalho-Ferreira,Joana Pereira de Molin Netto,Bárbara Dal Clemente,Ana Paula Grotti Tock,Lian Tufik,Sergio Mello,Marco Túlio de Dâmaso,Ana Raimunda |
dc.subject.por.fl_str_mv |
Inflammation bone turnover markers obesity adolescents weight loss |
topic |
Inflammation bone turnover markers obesity adolescents weight loss |
description |
ABSTRACT Objectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000300275 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000300275 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.20945/2359-3997000000039 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Archives of Endocrinology and Metabolism v.62 n.3 2018 reponame:Arquivos de Endocrinologia e Metabolismo (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos de Endocrinologia e Metabolismo (Online) |
collection |
Arquivos de Endocrinologia e Metabolismo (Online) |
repository.name.fl_str_mv |
Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||aem.editorial.office@endocrino.org.br |
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1752122515804651520 |