Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition

Detalhes bibliográficos
Autor(a) principal: Batistuzzo,Alice
Data de Publicação: 2020
Outros Autores: Ribeiro,Miriam Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000100089
Resumo: ABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1):89-95
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spelling Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognitionHypothyroidismpregnancyoffspringcognitionbehaviorABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1):89-95Sociedade Brasileira de Endocrinologia e Metabologia2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000100089Archives of Endocrinology and Metabolism v.64 n.1 2020reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000201info:eu-repo/semantics/openAccessBatistuzzo,AliceRibeiro,Miriam Oliveiraeng2020-03-09T00:00:00Zoai:scielo:S2359-39972020000100089Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2020-03-09T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
title Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
spellingShingle Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
Batistuzzo,Alice
Hypothyroidism
pregnancy
offspring
cognition
behavior
title_short Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
title_full Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
title_fullStr Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
title_full_unstemmed Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
title_sort Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
author Batistuzzo,Alice
author_facet Batistuzzo,Alice
Ribeiro,Miriam Oliveira
author_role author
author2 Ribeiro,Miriam Oliveira
author2_role author
dc.contributor.author.fl_str_mv Batistuzzo,Alice
Ribeiro,Miriam Oliveira
dc.subject.por.fl_str_mv Hypothyroidism
pregnancy
offspring
cognition
behavior
topic Hypothyroidism
pregnancy
offspring
cognition
behavior
description ABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1):89-95
publishDate 2020
dc.date.none.fl_str_mv 2020-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000100089
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000100089
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.20945/2359-3997000000201
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.64 n.1 2020
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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