Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast

Detalhes bibliográficos
Autor(a) principal: Legakis,Ioannis
Data de Publicação: 2016
Outros Autores: Mantzouridis,Timos, Bouboulis,George, Chrousos,George P.
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076
Resumo: ABSTRACT Objective In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast. Subjects and methods We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05. Results In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state. Conclusion These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.
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spelling Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fastAdipsinvisfatintype 2 diabetesfastinghumansABSTRACT Objective In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast. Subjects and methods We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05. Results In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state. Conclusion These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.Sociedade Brasileira de Endocrinologia e Metabologia2016-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076Archives of Endocrinology and Metabolism v.60 n.1 2016reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/2359-3997000000147info:eu-repo/semantics/openAccessLegakis,IoannisMantzouridis,TimosBouboulis,GeorgeChrousos,George P.eng2016-02-17T00:00:00Zoai:scielo:S2359-39972016000100076Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2016-02-17T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
title Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
spellingShingle Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
Legakis,Ioannis
Adipsin
visfatin
type 2 diabetes
fasting
humans
title_short Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
title_full Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
title_fullStr Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
title_full_unstemmed Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
title_sort Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
author Legakis,Ioannis
author_facet Legakis,Ioannis
Mantzouridis,Timos
Bouboulis,George
Chrousos,George P.
author_role author
author2 Mantzouridis,Timos
Bouboulis,George
Chrousos,George P.
author2_role author
author
author
dc.contributor.author.fl_str_mv Legakis,Ioannis
Mantzouridis,Timos
Bouboulis,George
Chrousos,George P.
dc.subject.por.fl_str_mv Adipsin
visfatin
type 2 diabetes
fasting
humans
topic Adipsin
visfatin
type 2 diabetes
fasting
humans
description ABSTRACT Objective In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast. Subjects and methods We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05. Results In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state. Conclusion These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2359-3997000000147
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism v.60 n.1 2016
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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