Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Arquivos de Endocrinologia e Metabolismo (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076 |
Resumo: | ABSTRACT Objective In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast. Subjects and methods We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05. Results In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state. Conclusion These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes. |
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Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fastAdipsinvisfatintype 2 diabetesfastinghumansABSTRACT Objective In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast. Subjects and methods We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05. Results In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state. Conclusion These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.Sociedade Brasileira de Endocrinologia e Metabologia2016-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076Archives of Endocrinology and Metabolism v.60 n.1 2016reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/2359-3997000000147info:eu-repo/semantics/openAccessLegakis,IoannisMantzouridis,TimosBouboulis,GeorgeChrousos,George P.eng2016-02-17T00:00:00Zoai:scielo:S2359-39972016000100076Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2016-02-17T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast |
title |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast |
spellingShingle |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast Legakis,Ioannis Adipsin visfatin type 2 diabetes fasting humans |
title_short |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast |
title_full |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast |
title_fullStr |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast |
title_full_unstemmed |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast |
title_sort |
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast |
author |
Legakis,Ioannis |
author_facet |
Legakis,Ioannis Mantzouridis,Timos Bouboulis,George Chrousos,George P. |
author_role |
author |
author2 |
Mantzouridis,Timos Bouboulis,George Chrousos,George P. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Legakis,Ioannis Mantzouridis,Timos Bouboulis,George Chrousos,George P. |
dc.subject.por.fl_str_mv |
Adipsin visfatin type 2 diabetes fasting humans |
topic |
Adipsin visfatin type 2 diabetes fasting humans |
description |
ABSTRACT Objective In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast. Subjects and methods We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05. Results In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state. Conclusion These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000100076 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2359-3997000000147 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Archives of Endocrinology and Metabolism v.60 n.1 2016 reponame:Arquivos de Endocrinologia e Metabolismo (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos de Endocrinologia e Metabolismo (Online) |
collection |
Arquivos de Endocrinologia e Metabolismo (Online) |
repository.name.fl_str_mv |
Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||aem.editorial.office@endocrino.org.br |
_version_ |
1752122513895194624 |