Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications

Detalhes bibliográficos
Autor(a) principal: Paz-Filho,Gilberto
Data de Publicação: 2012
Outros Autores: Mastronardi,Claudio, Franco,Carina Bertoldi, Wang,Kevin Boyang, Wong,Ma-Li, Licinio,Julio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000900001
Resumo: Leptin, the adipokine produced mainly by the white adipose tissue, plays important roles not only in the regulation of food intake, but also in controlling immunity and inflammation. It has been widely demonstrated that the absence of leptin leads to immune defects in animal and human models, ultimately increasing mortality. Leptin also regulates inflammation by means of actions on its receptor, that is widely spread across different immune cell populations. The molecular mechanisms by which leptin determines its biological actions have also been recently elucidated, and three intracellular pathways have been implicated in leptin actions: JAK-STAT, PI3K, and ERK 1/2. These pathways are closely regulated by intracellular proteins that decrease leptin biological activity. In this review, we discuss the molecular mechanisms by which leptin regulates immunity and inflammation, and associate those mechanisms with chronic inflammatory disorders. Arq Bras Endocrinol Metab. 2012;56(9):597-607
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spelling Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implicationsLeptinimmunityinflammationcytokinesLeptin, the adipokine produced mainly by the white adipose tissue, plays important roles not only in the regulation of food intake, but also in controlling immunity and inflammation. It has been widely demonstrated that the absence of leptin leads to immune defects in animal and human models, ultimately increasing mortality. Leptin also regulates inflammation by means of actions on its receptor, that is widely spread across different immune cell populations. The molecular mechanisms by which leptin determines its biological actions have also been recently elucidated, and three intracellular pathways have been implicated in leptin actions: JAK-STAT, PI3K, and ERK 1/2. These pathways are closely regulated by intracellular proteins that decrease leptin biological activity. In this review, we discuss the molecular mechanisms by which leptin regulates immunity and inflammation, and associate those mechanisms with chronic inflammatory disorders. Arq Bras Endocrinol Metab. 2012;56(9):597-607Sociedade Brasileira de Endocrinologia e Metabologia2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000900001Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.9 2012reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302012000900001info:eu-repo/semantics/openAccessPaz-Filho,GilbertoMastronardi,ClaudioFranco,Carina BertoldiWang,Kevin BoyangWong,Ma-LiLicinio,Julioeng2013-01-15T00:00:00Zoai:scielo:S0004-27302012000900001Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2013-01-15T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
title Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
spellingShingle Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
Paz-Filho,Gilberto
Leptin
immunity
inflammation
cytokines
title_short Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
title_full Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
title_fullStr Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
title_full_unstemmed Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
title_sort Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
author Paz-Filho,Gilberto
author_facet Paz-Filho,Gilberto
Mastronardi,Claudio
Franco,Carina Bertoldi
Wang,Kevin Boyang
Wong,Ma-Li
Licinio,Julio
author_role author
author2 Mastronardi,Claudio
Franco,Carina Bertoldi
Wang,Kevin Boyang
Wong,Ma-Li
Licinio,Julio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Paz-Filho,Gilberto
Mastronardi,Claudio
Franco,Carina Bertoldi
Wang,Kevin Boyang
Wong,Ma-Li
Licinio,Julio
dc.subject.por.fl_str_mv Leptin
immunity
inflammation
cytokines
topic Leptin
immunity
inflammation
cytokines
description Leptin, the adipokine produced mainly by the white adipose tissue, plays important roles not only in the regulation of food intake, but also in controlling immunity and inflammation. It has been widely demonstrated that the absence of leptin leads to immune defects in animal and human models, ultimately increasing mortality. Leptin also regulates inflammation by means of actions on its receptor, that is widely spread across different immune cell populations. The molecular mechanisms by which leptin determines its biological actions have also been recently elucidated, and three intracellular pathways have been implicated in leptin actions: JAK-STAT, PI3K, and ERK 1/2. These pathways are closely regulated by intracellular proteins that decrease leptin biological activity. In this review, we discuss the molecular mechanisms by which leptin regulates immunity and inflammation, and associate those mechanisms with chronic inflammatory disorders. Arq Bras Endocrinol Metab. 2012;56(9):597-607
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000900001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000900001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302012000900001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.9 2012
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
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reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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