Pseudotumor cerebri during Cushing's disease treatment with ketoconazole
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400008 |
Resumo: | Benign intracranial hypertension (Pseudotumor cerebri) has been described as related to the reduction in steroid levels in Cushing's disease (CD), especially after surgical remission. Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction. We describe here the case of a 12-year old girl with CD who developed benign intracranial hypertension during treatment with ketoconazole. She presented headache, vomiting, a black spot on her right temporal visual field, and signs of elevated intracranial pressure. Pituitary image was normal on magnetic resonance image (MRI), and all symptoms improved after treatment with acetazolamide. We call attention to the diagnosis of this disorder in CD patients, especially children on ketoconazole treatment, because it could be confounded with adrenal insufficiency and lead to definitive severe visual impairment. |
id |
SBEM-2_4fa535ca895bee2279a32a98ece3e6e2 |
---|---|
oai_identifier_str |
oai:scielo:S0004-27302011000400008 |
network_acronym_str |
SBEM-2 |
network_name_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository_id_str |
|
spelling |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazoleBenign intracranial hypertension (Pseudotumor cerebri) has been described as related to the reduction in steroid levels in Cushing's disease (CD), especially after surgical remission. Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction. We describe here the case of a 12-year old girl with CD who developed benign intracranial hypertension during treatment with ketoconazole. She presented headache, vomiting, a black spot on her right temporal visual field, and signs of elevated intracranial pressure. Pituitary image was normal on magnetic resonance image (MRI), and all symptoms improved after treatment with acetazolamide. We call attention to the diagnosis of this disorder in CD patients, especially children on ketoconazole treatment, because it could be confounded with adrenal insufficiency and lead to definitive severe visual impairment.Sociedade Brasileira de Endocrinologia e Metabologia2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400008Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.4 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000400008info:eu-repo/semantics/openAccessCostenaro,FabiolaRodrigues,Ticiana C.Ferreira,Nelson P.Costa,Tiago G. daSchuch,TiagoBoschi,VitorCzepielewski,Mauro A.eng2011-07-07T00:00:00Zoai:scielo:S0004-27302011000400008Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-07-07T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole |
title |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole |
spellingShingle |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole Costenaro,Fabiola |
title_short |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole |
title_full |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole |
title_fullStr |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole |
title_full_unstemmed |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole |
title_sort |
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole |
author |
Costenaro,Fabiola |
author_facet |
Costenaro,Fabiola Rodrigues,Ticiana C. Ferreira,Nelson P. Costa,Tiago G. da Schuch,Tiago Boschi,Vitor Czepielewski,Mauro A. |
author_role |
author |
author2 |
Rodrigues,Ticiana C. Ferreira,Nelson P. Costa,Tiago G. da Schuch,Tiago Boschi,Vitor Czepielewski,Mauro A. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Costenaro,Fabiola Rodrigues,Ticiana C. Ferreira,Nelson P. Costa,Tiago G. da Schuch,Tiago Boschi,Vitor Czepielewski,Mauro A. |
description |
Benign intracranial hypertension (Pseudotumor cerebri) has been described as related to the reduction in steroid levels in Cushing's disease (CD), especially after surgical remission. Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction. We describe here the case of a 12-year old girl with CD who developed benign intracranial hypertension during treatment with ketoconazole. She presented headache, vomiting, a black spot on her right temporal visual field, and signs of elevated intracranial pressure. Pituitary image was normal on magnetic resonance image (MRI), and all symptoms improved after treatment with acetazolamide. We call attention to the diagnosis of this disorder in CD patients, especially children on ketoconazole treatment, because it could be confounded with adrenal insufficiency and lead to definitive severe visual impairment. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27302011000400008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.4 2011 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
_version_ |
1754734811399847936 |