Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas

Detalhes bibliográficos
Autor(a) principal: Ribeiro,Rogerio Silicani
Data de Publicação: 2011
Outros Autores: Abucham,Julio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400005
Resumo: OBJETIVE: To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS: Open label, single-arm, prospective trial. Nine hypogonadal men (testosterone < 300 ng/dL and low/normal LH) with previously treated NFPA. Clomiphene (50 mg/day orally) for 12 weeks. Testosterone, estradiol, LH, FSH, prolactin and erectile function were evaluated before and after 10 days, 4, 8 and 12 weeks of clomiphene treatment. RESULTS: After clomiphene treatment, testosterone and erectile function improved in only one patient. In the remaining eight patients, testosterone levels decreased whereas LH, FSH, and estradiol remained unchanged. Insulin sensitivity increased in unresponsive patients. CONCLUSIONS: Compared with hypogonadal men with prolactinomas under dopaminergic therapy, clomiphene treatment failed to restore normal testosterone levels in most patients with conventionally treated NFPA.
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spelling Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomasNonfunctioning pituitary adenomahypogonadotropic hypogonadismclomiphenetestosteroneOBJETIVE: To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS: Open label, single-arm, prospective trial. Nine hypogonadal men (testosterone < 300 ng/dL and low/normal LH) with previously treated NFPA. Clomiphene (50 mg/day orally) for 12 weeks. Testosterone, estradiol, LH, FSH, prolactin and erectile function were evaluated before and after 10 days, 4, 8 and 12 weeks of clomiphene treatment. RESULTS: After clomiphene treatment, testosterone and erectile function improved in only one patient. In the remaining eight patients, testosterone levels decreased whereas LH, FSH, and estradiol remained unchanged. Insulin sensitivity increased in unresponsive patients. CONCLUSIONS: Compared with hypogonadal men with prolactinomas under dopaminergic therapy, clomiphene treatment failed to restore normal testosterone levels in most patients with conventionally treated NFPA.Sociedade Brasileira de Endocrinologia e Metabologia2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400005Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.55 n.4 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000400005info:eu-repo/semantics/openAccessRibeiro,Rogerio SilicaniAbucham,Julioeng2011-07-07T00:00:00Zoai:scielo:S0004-27302011000400005Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-07-07T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
spellingShingle Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
Ribeiro,Rogerio Silicani
Nonfunctioning pituitary adenoma
hypogonadotropic hypogonadism
clomiphene
testosterone
title_short Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_full Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_fullStr Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_full_unstemmed Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_sort Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
author Ribeiro,Rogerio Silicani
author_facet Ribeiro,Rogerio Silicani
Abucham,Julio
author_role author
author2 Abucham,Julio
author2_role author
dc.contributor.author.fl_str_mv Ribeiro,Rogerio Silicani
Abucham,Julio
dc.subject.por.fl_str_mv Nonfunctioning pituitary adenoma
hypogonadotropic hypogonadism
clomiphene
testosterone
topic Nonfunctioning pituitary adenoma
hypogonadotropic hypogonadism
clomiphene
testosterone
description OBJETIVE: To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS: Open label, single-arm, prospective trial. Nine hypogonadal men (testosterone < 300 ng/dL and low/normal LH) with previously treated NFPA. Clomiphene (50 mg/day orally) for 12 weeks. Testosterone, estradiol, LH, FSH, prolactin and erectile function were evaluated before and after 10 days, 4, 8 and 12 weeks of clomiphene treatment. RESULTS: After clomiphene treatment, testosterone and erectile function improved in only one patient. In the remaining eight patients, testosterone levels decreased whereas LH, FSH, and estradiol remained unchanged. Insulin sensitivity increased in unresponsive patients. CONCLUSIONS: Compared with hypogonadal men with prolactinomas under dopaminergic therapy, clomiphene treatment failed to restore normal testosterone levels in most patients with conventionally treated NFPA.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302011000400005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.55 n.4 2011
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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