Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

• Autor(a) principal: Piccoli,Jacqueline C. Escobar
• Data de Publicação: 2008
• Outros Autores: Gottlieb,Maria Gabriela Valle, Castro,Luciano, Bodanese,Luiz Carlos, Manenti,Euler Roberto Fernandes, Bogo,Mauricio Reis, Peres,Alessandra, Rocha,Maria Izabel U. M. da, Cruz,Ivana Beatrice Mânica da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000800027
• topic: NOS3 polymorphism; Nitric oxide synthase; Metabolic syndrome; Cardiovascular risk factors; Metabolic disorder

Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.