Adverse effects of growth hormone replacement therapy in children

Detalhes bibliográficos
Autor(a) principal: Souza,Flavio Moutinho
Data de Publicação: 2011
Outros Autores: Collett-Solberg,Paulo Ferrez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800009
Resumo: Human growth hormone (hGH) replacement therapy has been widely available for clinical purposes for more than fifty years. Starting in 1958, hGH was obtained from cadaveric pituitaries, but in 1985 the association between hGH therapy and Creutzfeldt-Jakob disease was reported. In the same year, the use of recombinant hGH (rhGH) was approved. Side effects of rhGH replacement therapy in children and adolescents include rash and pain at injection site, transient fever, prepubertal gynecomastia, arthralgia, edema, benign intracranial hypertension, insulin resistance, progression of scoliosis, and slipped capital femoral epiphysis. Since GH stimulates cell multiplication, development of neoplasms is a concern. We will review the side effects reported in all rhGH indications.
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spelling Adverse effects of growth hormone replacement therapy in childrenGrowth hormoneside effectsgynecomastiaintracranial hypertensionscoliosispediatricsshort statureHuman growth hormone (hGH) replacement therapy has been widely available for clinical purposes for more than fifty years. Starting in 1958, hGH was obtained from cadaveric pituitaries, but in 1985 the association between hGH therapy and Creutzfeldt-Jakob disease was reported. In the same year, the use of recombinant hGH (rhGH) was approved. Side effects of rhGH replacement therapy in children and adolescents include rash and pain at injection site, transient fever, prepubertal gynecomastia, arthralgia, edema, benign intracranial hypertension, insulin resistance, progression of scoliosis, and slipped capital femoral epiphysis. Since GH stimulates cell multiplication, development of neoplasms is a concern. We will review the side effects reported in all rhGH indications.Sociedade Brasileira de Endocrinologia e Metabologia2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800009Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.8 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000800009info:eu-repo/semantics/openAccessSouza,Flavio MoutinhoCollett-Solberg,Paulo Ferrezeng2012-01-03T00:00:00Zoai:scielo:S0004-27302011000800009Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2012-01-03T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Adverse effects of growth hormone replacement therapy in children
title Adverse effects of growth hormone replacement therapy in children
spellingShingle Adverse effects of growth hormone replacement therapy in children
Souza,Flavio Moutinho
Growth hormone
side effects
gynecomastia
intracranial hypertension
scoliosis
pediatrics
short stature
title_short Adverse effects of growth hormone replacement therapy in children
title_full Adverse effects of growth hormone replacement therapy in children
title_fullStr Adverse effects of growth hormone replacement therapy in children
title_full_unstemmed Adverse effects of growth hormone replacement therapy in children
title_sort Adverse effects of growth hormone replacement therapy in children
author Souza,Flavio Moutinho
author_facet Souza,Flavio Moutinho
Collett-Solberg,Paulo Ferrez
author_role author
author2 Collett-Solberg,Paulo Ferrez
author2_role author
dc.contributor.author.fl_str_mv Souza,Flavio Moutinho
Collett-Solberg,Paulo Ferrez
dc.subject.por.fl_str_mv Growth hormone
side effects
gynecomastia
intracranial hypertension
scoliosis
pediatrics
short stature
topic Growth hormone
side effects
gynecomastia
intracranial hypertension
scoliosis
pediatrics
short stature
description Human growth hormone (hGH) replacement therapy has been widely available for clinical purposes for more than fifty years. Starting in 1958, hGH was obtained from cadaveric pituitaries, but in 1985 the association between hGH therapy and Creutzfeldt-Jakob disease was reported. In the same year, the use of recombinant hGH (rhGH) was approved. Side effects of rhGH replacement therapy in children and adolescents include rash and pain at injection site, transient fever, prepubertal gynecomastia, arthralgia, edema, benign intracranial hypertension, insulin resistance, progression of scoliosis, and slipped capital femoral epiphysis. Since GH stimulates cell multiplication, development of neoplasms is a concern. We will review the side effects reported in all rhGH indications.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302011000800009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.8 2011
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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