Postnatal management of growth failure in children born small for gestational age

Detalhes bibliográficos
Autor(a) principal: Cardoso-Demartini,Adriane A.
Data de Publicação: 2019
Outros Autores: Boguszewski,Margaret C.S., Alves,Cresio A.D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal de Pediatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000300004
Resumo: Abstract Objectives: To discuss the etiology and growth consequences of small size at birth and the indications, effects, and safety of biosynthetic growth hormone therapy in children born small for gestational age. Source of data: A comprehensive and non-systematic search was carried out in the PubMed, LILACS, and SciELO databases from 1980 to the present day, using the terms "small for gestational age," "intrauterine growth restriction," and "growth hormone". The publications were critically selected by the authors. Data synthesis: Although the majority of children born small for gestational age show spontaneous catch-up growth during the first two years of life, some of them remain with short stature during childhood, with high risk of short stature in adult life. Treatment with growth hormone might be indicated, preferably after 2-4 years of age, in those small for gestational age children who remain short, without catch-up growth. Treatment aims to increase growth velocity and to reach a normal height during childhood and an adult height within target height. Response to growth hormone treatment is variable, with better growth response during the pre-pubertal period. Conclusions: Treatment with growth hormone in short children born small for gestational age is safe and effective to improve adult height. Efforts should be done to identify the etiology of small size at birth before treatment.
id SBPE-1_a9471a47b2196de413f9460569d6ebf2
oai_identifier_str oai:scielo:S0021-75572019000300004
network_acronym_str SBPE-1
network_name_str Jornal de Pediatria (Online)
repository_id_str
spelling Postnatal management of growth failure in children born small for gestational ageSmall for gestational ageCatch-upGrowth hormoneShort statureAdult heightAbstract Objectives: To discuss the etiology and growth consequences of small size at birth and the indications, effects, and safety of biosynthetic growth hormone therapy in children born small for gestational age. Source of data: A comprehensive and non-systematic search was carried out in the PubMed, LILACS, and SciELO databases from 1980 to the present day, using the terms "small for gestational age," "intrauterine growth restriction," and "growth hormone". The publications were critically selected by the authors. Data synthesis: Although the majority of children born small for gestational age show spontaneous catch-up growth during the first two years of life, some of them remain with short stature during childhood, with high risk of short stature in adult life. Treatment with growth hormone might be indicated, preferably after 2-4 years of age, in those small for gestational age children who remain short, without catch-up growth. Treatment aims to increase growth velocity and to reach a normal height during childhood and an adult height within target height. Response to growth hormone treatment is variable, with better growth response during the pre-pubertal period. Conclusions: Treatment with growth hormone in short children born small for gestational age is safe and effective to improve adult height. Efforts should be done to identify the etiology of small size at birth before treatment.Sociedade Brasileira de Pediatria2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000300004Jornal de Pediatria v.95 suppl.1 2019reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2018.10.015info:eu-repo/semantics/openAccessCardoso-Demartini,Adriane A.Boguszewski,Margaret C.S.Alves,Cresio A.D.eng2019-04-15T00:00:00Zoai:scielo:S0021-75572019000300004Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2019-04-15T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false
dc.title.none.fl_str_mv Postnatal management of growth failure in children born small for gestational age
title Postnatal management of growth failure in children born small for gestational age
spellingShingle Postnatal management of growth failure in children born small for gestational age
Cardoso-Demartini,Adriane A.
Small for gestational age
Catch-up
Growth hormone
Short stature
Adult height
title_short Postnatal management of growth failure in children born small for gestational age
title_full Postnatal management of growth failure in children born small for gestational age
title_fullStr Postnatal management of growth failure in children born small for gestational age
title_full_unstemmed Postnatal management of growth failure in children born small for gestational age
title_sort Postnatal management of growth failure in children born small for gestational age
author Cardoso-Demartini,Adriane A.
author_facet Cardoso-Demartini,Adriane A.
Boguszewski,Margaret C.S.
Alves,Cresio A.D.
author_role author
author2 Boguszewski,Margaret C.S.
Alves,Cresio A.D.
author2_role author
author
dc.contributor.author.fl_str_mv Cardoso-Demartini,Adriane A.
Boguszewski,Margaret C.S.
Alves,Cresio A.D.
dc.subject.por.fl_str_mv Small for gestational age
Catch-up
Growth hormone
Short stature
Adult height
topic Small for gestational age
Catch-up
Growth hormone
Short stature
Adult height
description Abstract Objectives: To discuss the etiology and growth consequences of small size at birth and the indications, effects, and safety of biosynthetic growth hormone therapy in children born small for gestational age. Source of data: A comprehensive and non-systematic search was carried out in the PubMed, LILACS, and SciELO databases from 1980 to the present day, using the terms "small for gestational age," "intrauterine growth restriction," and "growth hormone". The publications were critically selected by the authors. Data synthesis: Although the majority of children born small for gestational age show spontaneous catch-up growth during the first two years of life, some of them remain with short stature during childhood, with high risk of short stature in adult life. Treatment with growth hormone might be indicated, preferably after 2-4 years of age, in those small for gestational age children who remain short, without catch-up growth. Treatment aims to increase growth velocity and to reach a normal height during childhood and an adult height within target height. Response to growth hormone treatment is variable, with better growth response during the pre-pubertal period. Conclusions: Treatment with growth hormone in short children born small for gestational age is safe and effective to improve adult height. Efforts should be done to identify the etiology of small size at birth before treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000300004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572019000300004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jped.2018.10.015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Jornal de Pediatria v.95 suppl.1 2019
reponame:Jornal de Pediatria (Online)
instname:Sociedade Brasileira de Pediatria (SBP)
instacron:SBPE
instname_str Sociedade Brasileira de Pediatria (SBP)
instacron_str SBPE
institution SBPE
reponame_str Jornal de Pediatria (Online)
collection Jornal de Pediatria (Online)
repository.name.fl_str_mv Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)
repository.mail.fl_str_mv ||jped@jped.com.br
_version_ 1752122321814945792