Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene

Detalhes bibliográficos
Autor(a) principal: Vendramini,Marcio F.
Data de Publicação: 2010
Outros Autores: Gurgel,Lucimary C., Moisés,Regina S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000800003
Resumo: OBJECTIVE: To report the long-term (30-month) effect of the switch from insulin to sulfonylurea in a patient carrying the p.G53D (c.158G>A) mutation in KCNJ11 gene. SUBJECT AND METHOD: A 29-year-old male patient was diagnosed with diabetes in the third month of life and after identification of a heterozygous p.G53D mutation in the KCNJ11 gene, the therapy was switched from insulin to sulfonylurea. RESULTS: Long-term follow-up (30 months) showed that good metabolic control was maintained (HbA1c: 6.6%) and the glibenclamide dose could be reduced. CONCLUSION: Long-term therapy with sulfonylureas in patients with neonatal diabetes due to mutation in the KCNJ11 gene is safe and promotes sustained improvement of glycemic control.
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spelling Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 geneNeonatal diabetesKCNJ11 mutationsulfonylurea therapyOBJECTIVE: To report the long-term (30-month) effect of the switch from insulin to sulfonylurea in a patient carrying the p.G53D (c.158G>A) mutation in KCNJ11 gene. SUBJECT AND METHOD: A 29-year-old male patient was diagnosed with diabetes in the third month of life and after identification of a heterozygous p.G53D mutation in the KCNJ11 gene, the therapy was switched from insulin to sulfonylurea. RESULTS: Long-term follow-up (30 months) showed that good metabolic control was maintained (HbA1c: 6.6%) and the glibenclamide dose could be reduced. CONCLUSION: Long-term therapy with sulfonylureas in patients with neonatal diabetes due to mutation in the KCNJ11 gene is safe and promotes sustained improvement of glycemic control.Sociedade Brasileira de Endocrinologia e Metabologia2010-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000800003Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.8 2010reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302010000800003info:eu-repo/semantics/openAccessVendramini,Marcio F.Gurgel,Lucimary C.Moisés,Regina S.eng2011-02-02T00:00:00Zoai:scielo:S0004-27302010000800003Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-02-02T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
title Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
spellingShingle Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
Vendramini,Marcio F.
Neonatal diabetes
KCNJ11 mutation
sulfonylurea therapy
title_short Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
title_full Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
title_fullStr Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
title_full_unstemmed Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
title_sort Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene
author Vendramini,Marcio F.
author_facet Vendramini,Marcio F.
Gurgel,Lucimary C.
Moisés,Regina S.
author_role author
author2 Gurgel,Lucimary C.
Moisés,Regina S.
author2_role author
author
dc.contributor.author.fl_str_mv Vendramini,Marcio F.
Gurgel,Lucimary C.
Moisés,Regina S.
dc.subject.por.fl_str_mv Neonatal diabetes
KCNJ11 mutation
sulfonylurea therapy
topic Neonatal diabetes
KCNJ11 mutation
sulfonylurea therapy
description OBJECTIVE: To report the long-term (30-month) effect of the switch from insulin to sulfonylurea in a patient carrying the p.G53D (c.158G>A) mutation in KCNJ11 gene. SUBJECT AND METHOD: A 29-year-old male patient was diagnosed with diabetes in the third month of life and after identification of a heterozygous p.G53D mutation in the KCNJ11 gene, the therapy was switched from insulin to sulfonylurea. RESULTS: Long-term follow-up (30 months) showed that good metabolic control was maintained (HbA1c: 6.6%) and the glibenclamide dose could be reduced. CONCLUSION: Long-term therapy with sulfonylureas in patients with neonatal diabetes due to mutation in the KCNJ11 gene is safe and promotes sustained improvement of glycemic control.
publishDate 2010
dc.date.none.fl_str_mv 2010-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000800003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000800003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302010000800003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.8 2010
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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